Pharmacological Studies on Drug Interaction. VI. Combined Effect of Adenyl Compounds with Anti-pyretics and Analgesics

Combined effect of adenosine 2'-monophosphate (2'-AMP) and adenosine 3'-monophosphate (3'-AMP) with aminopyrine, Naproxen and morphine-HCl was investigated and results were as follows. 1) The hypothermic action of the combined use of aminopyrine with 2'-AMP and with 3'-AMP in mice was additive. 2) The antipyretic action of aminopyrine with 3'-AMP in adjuvant-induced fever rat was additive. 3) Effect of aminopyrine with 2'-AMP and 3'-AMP on writhing response induced by 0.6% acetic acid was additive, whereas naproxen with aminopyrine was slightly potentiated in mice. 4) 3'-AMP and 2'-AMP enhanced analgesic action of aminopyrine as tested by the hot plate method in mice. 5) 3'-AMP enhanced slightly analgesic action of morphine-HCl, as tested by the pressure method in mice, whereas 2'-AMP was ineffective. It is assumed that the combined effect of 2'-AMP or 3'-AMP with aminopyrine is additive, but that these drugs may not act in the same site of action.