Gram-scale Total Syntheses of Sarpagine Alkaloids and non-Natural Derivatives

This work describes the total synthesis of 3 members of the sarpagine alkaloid family and 10 non-natural congeners via an improved synthetic sequence which was designed to the point of gram-scale production of materials suited for SAR-studies. Furthermore, the manuscript details how the synthetic route was used to access the biogenetically completely unrelated stemona alkaloid parvineostemonine (34), posing a showcase for efficient synthetic design.