Active targeted drug delivery of MMP-2 sensitive polymeric nanoparticles

Active targeted drug delivery of MMP-2 sensitive polymeric nanoparticles

Novel matrix metalloproteinase 2 (MMP2)-sensitive nanoparticles (NPs) are developed with copolymers of TPGS 3350 -pp-PLGA and TPGS-folate to overcome some drawbacks of traditional anticancer formulations in drug delivery, such as short circulation time in blood, small drug accumulation at the tumor...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018-10, Vol.54 (79), p.1192-1195
Hauptverfasser: Pan, Jie, Li, Pei-Jiao, Wang, Yi, Chang, Lu, Wan, Dong, Wang, Hao
Format: Artikel
Sprache:eng
Schlagworte:
Blood circulation
Drug delivery systems
Formulations
Nanoparticles
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Zusammenfassung:Novel matrix metalloproteinase 2 (MMP2)-sensitive nanoparticles (NPs) are developed with copolymers of TPGS 3350 -pp-PLGA and TPGS-folate to overcome some drawbacks of traditional anticancer formulations in drug delivery, such as short circulation time in blood, small drug accumulation at the tumor site, low intracellular uptake, etc. MMP2-sensitive nanoparticles are developed with copolymers of TPGS 3350 -pp-PLGA and TPGS-folate in order to enhance the therapeutic efficiency of cancer.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc05504a