A clickable NHC-Au()-complex for the preparation of stimulus-responsive metallopeptide amphiphiles

A clickable NHC-Au()-complex for the preparation of stimulus-responsive metallopeptide amphiphiles

We report the synthesis of an alkyne functionalised NHC-Au( i )-complex which is conjugated with amphiphilic oligopeptides using a copper( i ) catalysed cycloaddition. The resulting Au( i )-metalloamphiphiles are shown to self-assemble into charge-regulated stimulus-responsive supramolecular polymer...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (68), p.9498-951
Hauptverfasser: Lewe, V, Preuss, M, Wo nica, E. A, Spitzer, D, Otter, R, Besenius, P
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Cycloaddition
Supramolecular polymers
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Zusammenfassung:We report the synthesis of an alkyne functionalised NHC-Au( i )-complex which is conjugated with amphiphilic oligopeptides using a copper( i ) catalysed cycloaddition. The resulting Au( i )-metalloamphiphiles are shown to self-assemble into charge-regulated stimulus-responsive supramolecular polymers in water via a weakly cooperative polymerisation mechanism. We report the synthesis of an alkyne functionalised NHC-Au( i )-complex which is conjugated with amphiphilic oligopeptides using a copper( i ) catalysed cycloaddition.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc05622f