Zika convalescent macaques display delayed induction of anamnestic cross-neutralizing antibody responses after dengue infection

Structural similarities between Zika (ZIKV) and dengue virus (DENV) leads to the induction of cross-reactive responses. We have previously demonstrated that ZIKV exposed macaques significantly enhance DENV viremia. Here we show that this enhancement of DENV infection occurred in the presence of high...

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Veröffentlicht in:	Emerging microbes & infections 2018-07, Vol.7 (1), p.1-11
Hauptverfasser:	Valiant, William G., Huang, Yan-Jang S., Vanlandingham, Dana L., Higgs, Stephen, Lewis, Mark G., Mattapallil, Joseph J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antibody Formation Antibody-Dependent Enhancement Coinfection - immunology Coinfection - virology Cross Reactions - immunology Dengue - immunology Dengue - virology Dengue Virus - immunology Disease Models, Animal Immunoglobulin G - immunology Infections Macaca - immunology Macaca - virology Neutralization Tests Zika virus Zika Virus - immunology Zika Virus Infection - immunology Zika Virus Infection - virology
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Zusammenfassung:	Structural similarities between Zika (ZIKV) and dengue virus (DENV) leads to the induction of cross-reactive responses. We have previously demonstrated that ZIKV exposed macaques significantly enhance DENV viremia. Here we show that this enhancement of DENV infection occurred in the presence of high levels of DENV cross-reactive IgG1 subclass of binding antibodies (bAb) with low DENV neutralizing antibody (nAb) activity (
ISSN:	2222-1751 2222-1751
DOI:	10.1038/s41426-018-0132-z