Highly efficient temperature-dependent chiral separation with a nucleotide-based coordination polymer

We report a new chiral coordination polymer, prepared from the cytidine 5′-monophosphate (CMP) nucleotide, capable of separating efficiently (enantiomeric excess of ca. 100%) racemic mixtures of l - and d -Asp in a temperature-dependent manner. The crystal structure of the host-guest adsorbate, with the d -Asp guest molecules loaded within its channels, could be solved allowing a direct visualization of the chiral recognition process. A chiral coordination polymer separates racemic mixtures of l - and d -aspartic acid with a d -Asp enantiomeric excess of ca. 100%.