The Level of Monocyte Chemoattractant Protein-1 May Be Affected by Several Factors

The authors aimed to study the effect of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on levels of circulatory monocyte chemoattractant protein-1 (MCP-1) and resistin in patients with type 2 diabetes mellitus. The secretion of MCP-1 is affected by age, body mass index, exercise, increased serum triglyceride concentration, insulin resistance, diabetes mellitus, cigarette smoking, coronary artery disease, hypertension, thrombus formation, tuberculosis, recurrent miscarriage, multiple sclerosis, HIV-neurological complications, nephropathy, inflammatory bowel disease, allergic asthma, rheumatoid arthritis, retinopathy due to oxygen-induced injury, tumor neovascularity, ischemia-related neuronal death, and drugs such as doxycycline, amlodipine, leukotriene receptor antagonists, and HMG-CoA reductase inhibitors [2]. While the authors concluded that the anti-inflammatory effects of n-3 PUFAs might be mediated by targeting MCP-1, they did not study any inflammatory biomarkers such as C-reactive protein, interleukin-6, and tumor necrosis factor-α in addition to MCP-1 and resistin.