Controlled photorelease of alkynoic acids and their decarboxylative deprotection for copper-catalyzed azide/alkyne cycloaddition

A controlled photorelease of alkynoic acids from the meso -methyl BODIPY photoremovable protecting group facilitates their subsequent efficient decarboxylation to give terminal alkynes for a Cu I -catalyzed azide/alkyne cycloaddition. The quantum efficiencies of the photochemical step and the kinetics of the click reaction step are reported. A controlled photorelease of alkynoic acids from a photoremovable protecting group (PPG) facilitates their subsequent decarboxylation to deliver terminal alkynes for a Cu I -catalyzed azide/alkyne cycloaddition.