Decompression sickness risk in rats by microbial removal of dissolved gas
We present a method for reducing the risk of decompression sickness (DCS) in rats exposed to high pressures of H . Suspensions of the human colonic microbe Methanobrevibacter smithii were introduced via a colonic cannula into the large intestines of the rats. While the rats breathed H in a hyperbari...
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Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-09, Vol.275 (3), p.R677 |
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container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
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creator | Kayar, Susan R Miller, Terry L Wolin, Meyer J Aukhert, Eugenia O Axley, Milton J Kiesow, Lutz A |
description | We present a method for reducing the risk of decompression sickness (DCS) in rats exposed to high pressures of H
. Suspensions of the human colonic microbe Methanobrevibacter smithii were introduced via a colonic cannula into the large intestines of the rats. While the rats breathed H
in a hyperbaric chamber, the microbe metabolized some of the H
diffusing into the intestine, converting H
and CO
to methane and water. Rate of release of methane from the rats, which was monitored by gas chromatography, varied with chamber H
pressure. This rate was higher during decompression than during compression, suggesting that during decompression the microbe was metabolizing H
stored in the rats' tissues. Rats treated with M. smithii had a 25% (5 of 20) incidence of DCS, which was significantly lower ( P < 0.01) than the 56% (28 of 50) incidence of untreated controls, brought on by a standardized compression and decompression sequence. Thus using a microbe in the intestine to remove an estimated 5% of the body burden of H
reduced DCS risk by more than one-half. This method of biochemical decompression may potentially facilitate human diving. |
format | Article |
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. Suspensions of the human colonic microbe Methanobrevibacter smithii were introduced via a colonic cannula into the large intestines of the rats. While the rats breathed H
in a hyperbaric chamber, the microbe metabolized some of the H
diffusing into the intestine, converting H
and CO
to methane and water. Rate of release of methane from the rats, which was monitored by gas chromatography, varied with chamber H
pressure. This rate was higher during decompression than during compression, suggesting that during decompression the microbe was metabolizing H
stored in the rats' tissues. Rats treated with M. smithii had a 25% (5 of 20) incidence of DCS, which was significantly lower ( P < 0.01) than the 56% (28 of 50) incidence of untreated controls, brought on by a standardized compression and decompression sequence. Thus using a microbe in the intestine to remove an estimated 5% of the body burden of H
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. Suspensions of the human colonic microbe Methanobrevibacter smithii were introduced via a colonic cannula into the large intestines of the rats. While the rats breathed H
in a hyperbaric chamber, the microbe metabolized some of the H
diffusing into the intestine, converting H
and CO
to methane and water. Rate of release of methane from the rats, which was monitored by gas chromatography, varied with chamber H
pressure. This rate was higher during decompression than during compression, suggesting that during decompression the microbe was metabolizing H
stored in the rats' tissues. Rats treated with M. smithii had a 25% (5 of 20) incidence of DCS, which was significantly lower ( P < 0.01) than the 56% (28 of 50) incidence of untreated controls, brought on by a standardized compression and decompression sequence. Thus using a microbe in the intestine to remove an estimated 5% of the body burden of H
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. Suspensions of the human colonic microbe Methanobrevibacter smithii were introduced via a colonic cannula into the large intestines of the rats. While the rats breathed H
in a hyperbaric chamber, the microbe metabolized some of the H
diffusing into the intestine, converting H
and CO
to methane and water. Rate of release of methane from the rats, which was monitored by gas chromatography, varied with chamber H
pressure. This rate was higher during decompression than during compression, suggesting that during decompression the microbe was metabolizing H
stored in the rats' tissues. Rats treated with M. smithii had a 25% (5 of 20) incidence of DCS, which was significantly lower ( P < 0.01) than the 56% (28 of 50) incidence of untreated controls, brought on by a standardized compression and decompression sequence. Thus using a microbe in the intestine to remove an estimated 5% of the body burden of H
reduced DCS risk by more than one-half. This method of biochemical decompression may potentially facilitate human diving.</abstract><cop>United States</cop><pmid>29586969</pmid></addata></record> |
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title | Decompression sickness risk in rats by microbial removal of dissolved gas |
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