Identification of a Monoclonal Antibody Specific for a Murine T3 Polypeptide
A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-ε ) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can bot...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1987-03, Vol.84 (5), p.1374-1378 |
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| container_end_page | 1378 |
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| container_issue | 5 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 84 |
| creator | Leo, Oberdan Foo, Michele Sachs, David H. Samelson, Lawrence E. Bluestone, Jeffrey A. |
| description | A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-ε ) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-ε as a cell surface protein involved in the transduction of activation signals. |
| doi_str_mv | 10.1073/pnas.84.5.1374 |
| format | Article |
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The antibody is specific for a 25-kDa protein component (T3-ε ) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-ε as a cell surface protein involved in the transduction of activation signals.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.84.5.1374</identifier><identifier>PMID: 2950524</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Antibodies ; Antibodies, immunoglobulins ; Antibodies, Monoclonal ; Antigens ; Antigens, Surface - analysis ; Biological and medical sciences ; CD3 Complex ; Cell Line ; Cell lines ; Cricetinae ; Cultured cells ; Flow Cytometry ; Fundamental and applied biological sciences. 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Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>K562 cells</subject><subject>Mice</subject><subject>Molecular immunology</subject><subject>Monoclonal antibodies</subject><subject>Receptors, Antigen, T-Cell - immunology</subject><subject>Spleen cells</subject><subject>T cell antigen receptors</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2L1DAYh4Mo67h69SAIPcjeWt98tEkOHpbFj4URBddzSNNEs2SSmrSL89_bMsMwXvSUw_P83rwvP4ReYmgwcPp2jLo0gjVtgylnj9AGg8R1xyQ8RhsAwmvBCHuKnpVyDwCyFXCBLohsoSVsg7a3g42Td97oyadYJVfp6nOKyYQUdaiuF9inYV99G61ZtcqlvCpz9tFWd7T6msJ-tOPkB_scPXE6FPvi-F6i7x_e3918qrdfPt7eXG9r0woy1dj2Xd8ygbuWYSt533VYS6k7Y4DpwUhqMfTAWd86PHBOiLWCuYEzOoAcHL1E7w5zx7nf2cEsF2Qd1Jj9Tue9Stqrv0n0P9WP9KAoMEbJkr865nP6NdsyqZ0vxoago01zUZwz0mEh_ytixgUTHSxicxBNTqVk607LYFBrT2rtSQmmWrX2tARen59w0o_FLPzNketidHBZR-PLSROYSuDybMw6_kTPvrn6F1duDmGyv6dFfHUQ78uU8tk6BDD9A5qJvCs</recordid><startdate>19870301</startdate><enddate>19870301</enddate><creator>Leo, Oberdan</creator><creator>Foo, Michele</creator><creator>Sachs, David H.</creator><creator>Samelson, Lawrence E.</creator><creator>Bluestone, Jeffrey A.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19870301</creationdate><title>Identification of a Monoclonal Antibody Specific for a Murine T3 Polypeptide</title><author>Leo, Oberdan ; Foo, Michele ; Sachs, David H. ; Samelson, Lawrence E. ; Bluestone, Jeffrey A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c582t-1eb6b54816541e97b661a99a6cc04adc93e10b074b5f1d7722ee84fd743d09df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, immunoglobulins</topic><topic>Antibodies, Monoclonal</topic><topic>Antigens</topic><topic>Antigens, Surface - analysis</topic><topic>Biological and medical sciences</topic><topic>CD3 Complex</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Cricetinae</topic><topic>Cultured cells</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>K562 cells</topic><topic>Mice</topic><topic>Molecular immunology</topic><topic>Monoclonal antibodies</topic><topic>Receptors, Antigen, T-Cell - immunology</topic><topic>Spleen cells</topic><topic>T cell antigen receptors</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leo, Oberdan</creatorcontrib><creatorcontrib>Foo, Michele</creatorcontrib><creatorcontrib>Sachs, David H.</creatorcontrib><creatorcontrib>Samelson, Lawrence E.</creatorcontrib><creatorcontrib>Bluestone, Jeffrey A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leo, Oberdan</au><au>Foo, Michele</au><au>Sachs, David H.</au><au>Samelson, Lawrence E.</au><au>Bluestone, Jeffrey A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of a Monoclonal Antibody Specific for a Murine T3 Polypeptide</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1987-03-01</date><risdate>1987</risdate><volume>84</volume><issue>5</issue><spage>1374</spage><epage>1378</epage><pages>1374-1378</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. 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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1987-03, Vol.84 (5), p.1374-1378 |
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| source | MEDLINE; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Antibodies Antibodies, immunoglobulins Antibodies, Monoclonal Antigens Antigens, Surface - analysis Biological and medical sciences CD3 Complex Cell Line Cell lines Cricetinae Cultured cells Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Humans K562 cells Mice Molecular immunology Monoclonal antibodies Receptors, Antigen, T-Cell - immunology Spleen cells T cell antigen receptors T lymphocytes T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology |
| title | Identification of a Monoclonal Antibody Specific for a Murine T3 Polypeptide |
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