Identification of a Monoclonal Antibody Specific for a Murine T3 Polypeptide

A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-ε ) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can bot...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1987-03, Vol.84 (5), p.1374-1378
Hauptverfasser:	Leo, Oberdan, Foo, Michele, Sachs, David H., Samelson, Lawrence E., Bluestone, Jeffrey A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, immunoglobulins Antibodies, Monoclonal Antigens Antigens, Surface - analysis Biological and medical sciences CD3 Complex Cell Line Cell lines Cricetinae Cultured cells Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Humans K562 cells Mice Molecular immunology Monoclonal antibodies Receptors, Antigen, T-Cell - immunology Spleen cells T cell antigen receptors T lymphocytes T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology
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Zusammenfassung:	A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-ε ) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-ε as a cell surface protein involved in the transduction of activation signals.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.84.5.1374