The Relationship between Th1/Th2 Balance and 1α, 25-Dihydroxyvitamin D 3 in Patients with Allergic Rhinitis

With regard to the correlation between T helper1/T helper2 (Th1/Th2) cell balance and 1α,25-dihydroxyvitamin D , active metabolite of vitamin D, we studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin (IL)-4, IL-10 and interferon-gamma (IFN-γ), which are important for immune response of patients with allergic rhinitis. Thirty adult patients diagnosed with allergic rhinitis (study group) and 40 healthy volunteers (control group) are examined in the research. IFN-γ, IL-4, IL-10, and total immunoglobulin E (IgE) levels from serum samples and vitamin D levels from plasma were determined in all patients. In IgE, IL-4, IL-10, IFN-γ, and 1α,25-dihydroxyvitamin D levels (p