Purification and Characterization of a Newly Identified Growth Factor Specific for Epithelial Cells

A growth factor specific for epithelial cells was identified in conditioned medium of a human embryonic lung fibroblast cell line, The factor, provisionally termed keratinocyte growth factor (KGF) because of its predominant activity on this cell type, was purified to homogeneity by a combination of...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1989-02, Vol.86 (3), p.802-806
Hauptverfasser:	Rubin, Jeffrey S., Osada, Hiroyuki, Finch, Paul W., Taylor, William G., Rudikoff, Stuart, Aaronson, Stuart A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cell Division - drug effects Cell growth Cell Line Cell lines Cells, Cultured Chromatography Chromatography, Affinity Chromatography, High Pressure Liquid Endothelial cells Epidermis - drug effects Epithelial cells epithelium Fibroblast growth factors Fibroblasts Fundamental and applied biological sciences. Psychology growth factors Growth Substances - isolation & purification Growth Substances - pharmacology Human growth Humans keratinocyte growth factor Keratinocytes man Mitogens Molecular Weight Protein hormones. Growth factors. Cytokines Proteins Ultrafiltration
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