A chiral template-driven synthesis of a 3'-deoxy-3'- 18 F-fluorothymidine precursor

A chiral template-driven synthesis of a 3'-deoxy-3'- 18 F-fluorothymidine precursor

An asymmetric synthesis of a 3'-deoxy-3'- F-fluorothymidine ( F-FLT) precursor has been developed wherein the deoxysugar moiety was synthesized using a novel Ga-mediated allylation of (R)-2,3-cyclohexylideneglyceraldehyde as the key step. The synthesis deviates significantly from the previ...

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Veröffentlicht in:European journal of medicinal chemistry 2018-01, Vol.143, p.1457
Hauptverfasser: Dey, Papiya, Ajish Kumar, K S, Sharma, Anubha, Chattopadhyay, Subrata
Format: Artikel
Sprache:eng
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Zusammenfassung:An asymmetric synthesis of a 3'-deoxy-3'- F-fluorothymidine ( F-FLT) precursor has been developed wherein the deoxysugar moiety was synthesized using a novel Ga-mediated allylation of (R)-2,3-cyclohexylideneglyceraldehyde as the key step. The synthesis deviates significantly from the previous syntheses of the F-FLT precursors wherein the expensive starting material, thymidine was used.
ISSN:1768-3254
DOI:10.1016/j.ejmech.2017.10.047