Associations of prenatal and early childhood mercury exposure with autistic behaviors at 5years of age: The Mothers and Children's Environmental Health (MOCEH) study
•We explored the associations between blood mercury levels and autistic behaviors.•This study involved an ongoing multi-center prospective birth cohort.•Blood mercury levels were repeatedly measured from early pregnancy to 3years.•Autistic behaviors were assessed at 5years with the Social Responsive...
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| Veröffentlicht in: | The Science of the total environment 2017-12, Vol.605-606, p.251-257 |
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| container_title | The Science of the total environment |
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| creator | Ryu, Jia Ha, Eun-Hee Kim, Boong-Nyun Ha, Mina Kim, Yangho Park, Hyesook Hong, Yun-Chul Kim, Kyoung-Nam |
| description | •We explored the associations between blood mercury levels and autistic behaviors.•This study involved an ongoing multi-center prospective birth cohort.•Blood mercury levels were repeatedly measured from early pregnancy to 3years.•Autistic behaviors were assessed at 5years with the Social Responsiveness Scale.•Prenatal and early childhood mercury levels were associated with autistic behaviors.
[Display omitted]
Although mercury is an established neurotoxin, only few longitudinal studies have investigated the association between prenatal and early childhood mercury exposure and autistic behaviors.
We conducted a longitudinal cohort study using an ongoing prospective birth cohort initiated in 2006, wherein blood mercury levels were measured at early and late pregnancy; in cord blood; and at 2 and 3years of age. We analyzed 458 mother-child pairs. Autistic behaviors were assessed using the Social Responsiveness Scale (SRS) at 5years of age. Both continuous SRS T-scores and T-scores dichotomized by a score of ≥60 or |
| doi_str_mv | 10.1016/j.scitotenv.2017.06.227 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_pubme</sourceid><recordid>TN_cdi_pubmed_primary_28667852</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0048969717316479</els_id><sourcerecordid>S0048969717316479</sourcerecordid><originalsourceid>FETCH-LOGICAL-e1142-cce4d6d0b49f761b7a1b8295e70fbe8a520b07b85bd5ed2424284265e4c87a603</originalsourceid><addsrcrecordid>eNo9kc9u1DAQhy1ERZfCK4BvwCGp7Sa2w221WthKrXopZ8t_ZolX2XhlO1vyQLwnDoWOD3Pw-PuN_CH0kZKaEsqvD3WyPocM47lmhIqa8Jox8QqtqBRdRQnjr9GKkEZWHe_EJXqb0oGUEpK-QZdMci5ky1bo9zqlYL3OPowJhz0-RRh11gPWo8Og4zBj2_vB9SE4fIRopzhj-HUKaYqAn3zusZ6yT9lbbKDXZx9iwjrjdi6v_yL1T_iKH3vA9yH3sNwW9GaBlqxPCW_Hs49hPMK45O5ADwX6-f5hs919wSlPbn6HLvZ6SPD-X79CP75tHze76u7h--1mfVcBpQ2rrIXGcUdM0-0Fp0ZoaiTrWhBkb0DqlhFDhJGtcS041pQjG8ZbaKwUmpObK_ThmXuazBGcOkV_1HFW__-rDKyfB6BscfYQVfEAowXnI9isXPCKErU4Ugf14kgtjhThqji6-QM_LomO</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Associations of prenatal and early childhood mercury exposure with autistic behaviors at 5years of age: The Mothers and Children's Environmental Health (MOCEH) study</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Ryu, Jia ; Ha, Eun-Hee ; Kim, Boong-Nyun ; Ha, Mina ; Kim, Yangho ; Park, Hyesook ; Hong, Yun-Chul ; Kim, Kyoung-Nam</creator><creatorcontrib>Ryu, Jia ; Ha, Eun-Hee ; Kim, Boong-Nyun ; Ha, Mina ; Kim, Yangho ; Park, Hyesook ; Hong, Yun-Chul ; Kim, Kyoung-Nam</creatorcontrib><description>•We explored the associations between blood mercury levels and autistic behaviors.•This study involved an ongoing multi-center prospective birth cohort.•Blood mercury levels were repeatedly measured from early pregnancy to 3years.•Autistic behaviors were assessed at 5years with the Social Responsiveness Scale.•Prenatal and early childhood mercury levels were associated with autistic behaviors.
[Display omitted]
Although mercury is an established neurotoxin, only few longitudinal studies have investigated the association between prenatal and early childhood mercury exposure and autistic behaviors.
We conducted a longitudinal cohort study using an ongoing prospective birth cohort initiated in 2006, wherein blood mercury levels were measured at early and late pregnancy; in cord blood; and at 2 and 3years of age. We analyzed 458 mother-child pairs. Autistic behaviors were assessed using the Social Responsiveness Scale (SRS) at 5years of age. Both continuous SRS T-scores and T-scores dichotomized by a score of ≥60 or <60 were used as outcomes.
The geometric mean of mercury concentrations in cord blood was 5.52μg/L. In adjusted models, a doubling of blood mercury levels at late pregnancy (β=1.84, 95% confidence interval [CI]: 0.39, 3.29), in cord blood (β=2.24, 95% CI: 0.22, 4.27), and at 2years (β=2.12, 95% CI: 0.54, 3.70) and 3years (β=2.80, 95% CI: 0.89, 4.72) of age was positively associated with the SRS T-scores. When the SRS T-scores were dichotomized, we observed positive associations with mercury levels at late pregnancy (relative risk [RR]=1.31, 95% CI: 1.08, 1.60) and in cord blood (RR=1.28, 95% CI: 1.01, 1.63).
We found that blood mercury levels at late pregnancy and early childhood were associated with more autistic behaviors in children at 5years of age. Further study on the long-term effects of mercury exposure is recommended.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2017.06.227</identifier><identifier>PMID: 28667852</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Autistic behavior ; Autistic Disorder - epidemiology ; Birth cohort ; Blood mercury ; Child, Preschool ; Early childhood exposure ; Environmental Health ; Female ; Fetal Blood - chemistry ; Humans ; Longitudinal Studies ; Male ; Mercury - adverse effects ; Mercury - blood ; Mothers ; Pregnancy ; Prenatal exposure ; Prenatal Exposure Delayed Effects - epidemiology ; Prospective Studies</subject><ispartof>The Science of the total environment, 2017-12, Vol.605-606, p.251-257</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.scitotenv.2017.06.227$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28667852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryu, Jia</creatorcontrib><creatorcontrib>Ha, Eun-Hee</creatorcontrib><creatorcontrib>Kim, Boong-Nyun</creatorcontrib><creatorcontrib>Ha, Mina</creatorcontrib><creatorcontrib>Kim, Yangho</creatorcontrib><creatorcontrib>Park, Hyesook</creatorcontrib><creatorcontrib>Hong, Yun-Chul</creatorcontrib><creatorcontrib>Kim, Kyoung-Nam</creatorcontrib><title>Associations of prenatal and early childhood mercury exposure with autistic behaviors at 5years of age: The Mothers and Children's Environmental Health (MOCEH) study</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>•We explored the associations between blood mercury levels and autistic behaviors.•This study involved an ongoing multi-center prospective birth cohort.•Blood mercury levels were repeatedly measured from early pregnancy to 3years.•Autistic behaviors were assessed at 5years with the Social Responsiveness Scale.•Prenatal and early childhood mercury levels were associated with autistic behaviors.
[Display omitted]
Although mercury is an established neurotoxin, only few longitudinal studies have investigated the association between prenatal and early childhood mercury exposure and autistic behaviors.
We conducted a longitudinal cohort study using an ongoing prospective birth cohort initiated in 2006, wherein blood mercury levels were measured at early and late pregnancy; in cord blood; and at 2 and 3years of age. We analyzed 458 mother-child pairs. Autistic behaviors were assessed using the Social Responsiveness Scale (SRS) at 5years of age. Both continuous SRS T-scores and T-scores dichotomized by a score of ≥60 or <60 were used as outcomes.
The geometric mean of mercury concentrations in cord blood was 5.52μg/L. In adjusted models, a doubling of blood mercury levels at late pregnancy (β=1.84, 95% confidence interval [CI]: 0.39, 3.29), in cord blood (β=2.24, 95% CI: 0.22, 4.27), and at 2years (β=2.12, 95% CI: 0.54, 3.70) and 3years (β=2.80, 95% CI: 0.89, 4.72) of age was positively associated with the SRS T-scores. When the SRS T-scores were dichotomized, we observed positive associations with mercury levels at late pregnancy (relative risk [RR]=1.31, 95% CI: 1.08, 1.60) and in cord blood (RR=1.28, 95% CI: 1.01, 1.63).
We found that blood mercury levels at late pregnancy and early childhood were associated with more autistic behaviors in children at 5years of age. Further study on the long-term effects of mercury exposure is recommended.</description><subject>Adult</subject><subject>Autistic behavior</subject><subject>Autistic Disorder - epidemiology</subject><subject>Birth cohort</subject><subject>Blood mercury</subject><subject>Child, Preschool</subject><subject>Early childhood exposure</subject><subject>Environmental Health</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Mercury - adverse effects</subject><subject>Mercury - blood</subject><subject>Mothers</subject><subject>Pregnancy</subject><subject>Prenatal exposure</subject><subject>Prenatal Exposure Delayed Effects - epidemiology</subject><subject>Prospective Studies</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc9u1DAQhy1ERZfCK4BvwCGp7Sa2w221WthKrXopZ8t_ZolX2XhlO1vyQLwnDoWOD3Pw-PuN_CH0kZKaEsqvD3WyPocM47lmhIqa8Jox8QqtqBRdRQnjr9GKkEZWHe_EJXqb0oGUEpK-QZdMci5ky1bo9zqlYL3OPowJhz0-RRh11gPWo8Og4zBj2_vB9SE4fIRopzhj-HUKaYqAn3zusZ6yT9lbbKDXZx9iwjrjdi6v_yL1T_iKH3vA9yH3sNwW9GaBlqxPCW_Hs49hPMK45O5ADwX6-f5hs919wSlPbn6HLvZ6SPD-X79CP75tHze76u7h--1mfVcBpQ2rrIXGcUdM0-0Fp0ZoaiTrWhBkb0DqlhFDhJGtcS041pQjG8ZbaKwUmpObK_ThmXuazBGcOkV_1HFW__-rDKyfB6BscfYQVfEAowXnI9isXPCKErU4Ugf14kgtjhThqji6-QM_LomO</recordid><startdate>20171215</startdate><enddate>20171215</enddate><creator>Ryu, Jia</creator><creator>Ha, Eun-Hee</creator><creator>Kim, Boong-Nyun</creator><creator>Ha, Mina</creator><creator>Kim, Yangho</creator><creator>Park, Hyesook</creator><creator>Hong, Yun-Chul</creator><creator>Kim, Kyoung-Nam</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20171215</creationdate><title>Associations of prenatal and early childhood mercury exposure with autistic behaviors at 5years of age: The Mothers and Children's Environmental Health (MOCEH) study</title><author>Ryu, Jia ; Ha, Eun-Hee ; Kim, Boong-Nyun ; Ha, Mina ; Kim, Yangho ; Park, Hyesook ; Hong, Yun-Chul ; Kim, Kyoung-Nam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e1142-cce4d6d0b49f761b7a1b8295e70fbe8a520b07b85bd5ed2424284265e4c87a603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Autistic behavior</topic><topic>Autistic Disorder - epidemiology</topic><topic>Birth cohort</topic><topic>Blood mercury</topic><topic>Child, Preschool</topic><topic>Early childhood exposure</topic><topic>Environmental Health</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Mercury - adverse effects</topic><topic>Mercury - blood</topic><topic>Mothers</topic><topic>Pregnancy</topic><topic>Prenatal exposure</topic><topic>Prenatal Exposure Delayed Effects - epidemiology</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ryu, Jia</creatorcontrib><creatorcontrib>Ha, Eun-Hee</creatorcontrib><creatorcontrib>Kim, Boong-Nyun</creatorcontrib><creatorcontrib>Ha, Mina</creatorcontrib><creatorcontrib>Kim, Yangho</creatorcontrib><creatorcontrib>Park, Hyesook</creatorcontrib><creatorcontrib>Hong, Yun-Chul</creatorcontrib><creatorcontrib>Kim, Kyoung-Nam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ryu, Jia</au><au>Ha, Eun-Hee</au><au>Kim, Boong-Nyun</au><au>Ha, Mina</au><au>Kim, Yangho</au><au>Park, Hyesook</au><au>Hong, Yun-Chul</au><au>Kim, Kyoung-Nam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of prenatal and early childhood mercury exposure with autistic behaviors at 5years of age: The Mothers and Children's Environmental Health (MOCEH) study</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2017-12-15</date><risdate>2017</risdate><volume>605-606</volume><spage>251</spage><epage>257</epage><pages>251-257</pages><issn>0048-9697</issn><eissn>1879-1026</eissn><abstract>•We explored the associations between blood mercury levels and autistic behaviors.•This study involved an ongoing multi-center prospective birth cohort.•Blood mercury levels were repeatedly measured from early pregnancy to 3years.•Autistic behaviors were assessed at 5years with the Social Responsiveness Scale.•Prenatal and early childhood mercury levels were associated with autistic behaviors.
[Display omitted]
Although mercury is an established neurotoxin, only few longitudinal studies have investigated the association between prenatal and early childhood mercury exposure and autistic behaviors.
We conducted a longitudinal cohort study using an ongoing prospective birth cohort initiated in 2006, wherein blood mercury levels were measured at early and late pregnancy; in cord blood; and at 2 and 3years of age. We analyzed 458 mother-child pairs. Autistic behaviors were assessed using the Social Responsiveness Scale (SRS) at 5years of age. Both continuous SRS T-scores and T-scores dichotomized by a score of ≥60 or <60 were used as outcomes.
The geometric mean of mercury concentrations in cord blood was 5.52μg/L. In adjusted models, a doubling of blood mercury levels at late pregnancy (β=1.84, 95% confidence interval [CI]: 0.39, 3.29), in cord blood (β=2.24, 95% CI: 0.22, 4.27), and at 2years (β=2.12, 95% CI: 0.54, 3.70) and 3years (β=2.80, 95% CI: 0.89, 4.72) of age was positively associated with the SRS T-scores. When the SRS T-scores were dichotomized, we observed positive associations with mercury levels at late pregnancy (relative risk [RR]=1.31, 95% CI: 1.08, 1.60) and in cord blood (RR=1.28, 95% CI: 1.01, 1.63).
We found that blood mercury levels at late pregnancy and early childhood were associated with more autistic behaviors in children at 5years of age. Further study on the long-term effects of mercury exposure is recommended.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28667852</pmid><doi>10.1016/j.scitotenv.2017.06.227</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Autistic behavior Autistic Disorder - epidemiology Birth cohort Blood mercury Child, Preschool Early childhood exposure Environmental Health Female Fetal Blood - chemistry Humans Longitudinal Studies Male Mercury - adverse effects Mercury - blood Mothers Pregnancy Prenatal exposure Prenatal Exposure Delayed Effects - epidemiology Prospective Studies |
| title | Associations of prenatal and early childhood mercury exposure with autistic behaviors at 5years of age: The Mothers and Children's Environmental Health (MOCEH) study |
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