Associations of prenatal and early childhood mercury exposure with autistic behaviors at 5years of age: The Mothers and Children's Environmental Health (MOCEH) study

•We explored the associations between blood mercury levels and autistic behaviors.•This study involved an ongoing multi-center prospective birth cohort.•Blood mercury levels were repeatedly measured from early pregnancy to 3years.•Autistic behaviors were assessed at 5years with the Social Responsive...

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Veröffentlicht in:The Science of the total environment 2017-12, Vol.605-606, p.251-257
Hauptverfasser: Ryu, Jia, Ha, Eun-Hee, Kim, Boong-Nyun, Ha, Mina, Kim, Yangho, Park, Hyesook, Hong, Yun-Chul, Kim, Kyoung-Nam
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Sprache:eng
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Zusammenfassung:•We explored the associations between blood mercury levels and autistic behaviors.•This study involved an ongoing multi-center prospective birth cohort.•Blood mercury levels were repeatedly measured from early pregnancy to 3years.•Autistic behaviors were assessed at 5years with the Social Responsiveness Scale.•Prenatal and early childhood mercury levels were associated with autistic behaviors. [Display omitted] Although mercury is an established neurotoxin, only few longitudinal studies have investigated the association between prenatal and early childhood mercury exposure and autistic behaviors. We conducted a longitudinal cohort study using an ongoing prospective birth cohort initiated in 2006, wherein blood mercury levels were measured at early and late pregnancy; in cord blood; and at 2 and 3years of age. We analyzed 458 mother-child pairs. Autistic behaviors were assessed using the Social Responsiveness Scale (SRS) at 5years of age. Both continuous SRS T-scores and T-scores dichotomized by a score of ≥60 or
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2017.06.227