Comparative analysis of selected cag PAI genes and different vac A genotypes in Iranian and Turkish H. pylori -positive patients suffering from gastric adenocarcinoma and active chronic gastritis

is a pathogen that colonizes a majority of the world's population. Genetic diversity within the virulence genes of bacteria such as PAI and A may have a modified effect on the pathogenic potential of the bacteria. This study aimed to investigate which genes can be suggested as potentially related virulence factors for -associated active chronic gastritis and stomach adenocarcinoma in the northwest of Iran and south of Turkey. Formalin-fixed, paraffin-embedded stomach biopsy tissue samples were obtained from Iranian and Turkish patients from selected geographical regions. The prevalence of selected PAI genes and A genotypes were studied in -positive samples by using polymerase chain reaction and specific primers. Out of 320 patients, was detected in 28.43% of patients. We found that the and genes with mean prevalences of 82.41%, 71.42%, and 69.23%, respectively, were dominant in Iranian and Turkish patients. In the south of Turkey and northwest of Iran the studied genes were homogeneous and there were no significant differences in bacterial genetics. The results of this study indicate that and are dominant genes in people with gastric disorders in our selected geographical regions.