HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G Alert
The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into G , a cellular state in which they have an increased functional ability to activate and participate in tissue repair...
Gespeichert in:
| Veröffentlicht in: | Cell reports (Cambridge) 2017-04, Vol.19 (3), p.479 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | 479 |
| container_title | Cell reports (Cambridge) |
| container_volume | 19 |
| creator | Rodgers, Joseph T Schroeder, Matthew D Ma, Chanthia Rando, Thomas A |
| description | The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into G
, a cellular state in which they have an increased functional ability to activate and participate in tissue repair. However, the precise molecular signals that induce G
in stem cells have remained elusive. Here, we show that the injury-induced regulation of hepatocyte growth factor (HGF) proteolytic processing via the systemic protease, hepatocyte growth factor activator (HGFA), stimulates G
in skeletal muscle stem cells (MuSCs) and fibro-adipogenic progenitors (FAPs). We demonstrate that administering active HGFA to animals is sufficient to induce G
in stem cells throughout the body and to significantly accelerate the processes of stem cell activation and tissue repair. Our data suggest that factors that induce G
will have broad therapeutic applications for regenerative medicine and wound healing. |
| doi_str_mv | 10.1016/j.celrep.2017.03.066 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_28423312</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>28423312</sourcerecordid><originalsourceid>FETCH-pubmed_primary_284233123</originalsourceid><addsrcrecordid>eNqFzrEKwjAUBdAgiIr6ByLvBxrz0lJ1FLHqqu4S26empGlJ0qF_bwedvcvlwhkuYwsUHAWmq5LnZBw1XApccxFzkaYDNpESMUKZrMds7n0p-qQCcZuM2FhuEhnHKCfscTpmOzh7UBbOtmxdF13o1RoVqIBr5wNVOodM5aF2EN4q9Kpoc_L9ILg5Zb0OurZQP-HaY9iTMR60DTUcYWfIhRkbPpXxNP_2lC2zw21_ipr2UVFxb5yulOvuv1PxX_ABuJtIzw</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G Alert</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Cell Press Free Archives</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Rodgers, Joseph T ; Schroeder, Matthew D ; Ma, Chanthia ; Rando, Thomas A</creator><creatorcontrib>Rodgers, Joseph T ; Schroeder, Matthew D ; Ma, Chanthia ; Rando, Thomas A</creatorcontrib><description>The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into G
, a cellular state in which they have an increased functional ability to activate and participate in tissue repair. However, the precise molecular signals that induce G
in stem cells have remained elusive. Here, we show that the injury-induced regulation of hepatocyte growth factor (HGF) proteolytic processing via the systemic protease, hepatocyte growth factor activator (HGFA), stimulates G
in skeletal muscle stem cells (MuSCs) and fibro-adipogenic progenitors (FAPs). We demonstrate that administering active HGFA to animals is sufficient to induce G
in stem cells throughout the body and to significantly accelerate the processes of stem cell activation and tissue repair. Our data suggest that factors that induce G
will have broad therapeutic applications for regenerative medicine and wound healing.</description><identifier>EISSN: 2211-1247</identifier><identifier>DOI: 10.1016/j.celrep.2017.03.066</identifier><identifier>PMID: 28423312</identifier><language>eng</language><publisher>United States</publisher><subject>Adipocytes - cytology ; Adipocytes - drug effects ; Adipogenesis - drug effects ; Animals ; Cell Cycle - drug effects ; Fibroblasts - cytology ; Fibroblasts - drug effects ; Kinetics ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle, Skeletal - cytology ; Serine Endopeptidases - administration & dosage ; Serine Endopeptidases - pharmacology ; Serum - metabolism ; Stem Cells - cytology ; Stem Cells - drug effects ; Stem Cells - metabolism ; Wound Healing - drug effects</subject><ispartof>Cell reports (Cambridge), 2017-04, Vol.19 (3), p.479</ispartof><rights>Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28423312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodgers, Joseph T</creatorcontrib><creatorcontrib>Schroeder, Matthew D</creatorcontrib><creatorcontrib>Ma, Chanthia</creatorcontrib><creatorcontrib>Rando, Thomas A</creatorcontrib><title>HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G Alert</title><title>Cell reports (Cambridge)</title><addtitle>Cell Rep</addtitle><description>The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into G
, a cellular state in which they have an increased functional ability to activate and participate in tissue repair. However, the precise molecular signals that induce G
in stem cells have remained elusive. Here, we show that the injury-induced regulation of hepatocyte growth factor (HGF) proteolytic processing via the systemic protease, hepatocyte growth factor activator (HGFA), stimulates G
in skeletal muscle stem cells (MuSCs) and fibro-adipogenic progenitors (FAPs). We demonstrate that administering active HGFA to animals is sufficient to induce G
in stem cells throughout the body and to significantly accelerate the processes of stem cell activation and tissue repair. Our data suggest that factors that induce G
will have broad therapeutic applications for regenerative medicine and wound healing.</description><subject>Adipocytes - cytology</subject><subject>Adipocytes - drug effects</subject><subject>Adipogenesis - drug effects</subject><subject>Animals</subject><subject>Cell Cycle - drug effects</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - drug effects</subject><subject>Kinetics</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Muscle, Skeletal - cytology</subject><subject>Serine Endopeptidases - administration & dosage</subject><subject>Serine Endopeptidases - pharmacology</subject><subject>Serum - metabolism</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - drug effects</subject><subject>Stem Cells - metabolism</subject><subject>Wound Healing - drug effects</subject><issn>2211-1247</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFzrEKwjAUBdAgiIr6ByLvBxrz0lJ1FLHqqu4S26empGlJ0qF_bwedvcvlwhkuYwsUHAWmq5LnZBw1XApccxFzkaYDNpESMUKZrMds7n0p-qQCcZuM2FhuEhnHKCfscTpmOzh7UBbOtmxdF13o1RoVqIBr5wNVOodM5aF2EN4q9Kpoc_L9ILg5Zb0OurZQP-HaY9iTMR60DTUcYWfIhRkbPpXxNP_2lC2zw21_ipr2UVFxb5yulOvuv1PxX_ABuJtIzw</recordid><startdate>20170418</startdate><enddate>20170418</enddate><creator>Rodgers, Joseph T</creator><creator>Schroeder, Matthew D</creator><creator>Ma, Chanthia</creator><creator>Rando, Thomas A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20170418</creationdate><title>HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G Alert</title><author>Rodgers, Joseph T ; Schroeder, Matthew D ; Ma, Chanthia ; Rando, Thomas A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_284233123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipocytes - cytology</topic><topic>Adipocytes - drug effects</topic><topic>Adipogenesis - drug effects</topic><topic>Animals</topic><topic>Cell Cycle - drug effects</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - drug effects</topic><topic>Kinetics</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Muscle, Skeletal - cytology</topic><topic>Serine Endopeptidases - administration & dosage</topic><topic>Serine Endopeptidases - pharmacology</topic><topic>Serum - metabolism</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - drug effects</topic><topic>Stem Cells - metabolism</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodgers, Joseph T</creatorcontrib><creatorcontrib>Schroeder, Matthew D</creatorcontrib><creatorcontrib>Ma, Chanthia</creatorcontrib><creatorcontrib>Rando, Thomas A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cell reports (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodgers, Joseph T</au><au>Schroeder, Matthew D</au><au>Ma, Chanthia</au><au>Rando, Thomas A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G Alert</atitle><jtitle>Cell reports (Cambridge)</jtitle><addtitle>Cell Rep</addtitle><date>2017-04-18</date><risdate>2017</risdate><volume>19</volume><issue>3</issue><spage>479</spage><pages>479-</pages><eissn>2211-1247</eissn><abstract>The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into G
, a cellular state in which they have an increased functional ability to activate and participate in tissue repair. However, the precise molecular signals that induce G
in stem cells have remained elusive. Here, we show that the injury-induced regulation of hepatocyte growth factor (HGF) proteolytic processing via the systemic protease, hepatocyte growth factor activator (HGFA), stimulates G
in skeletal muscle stem cells (MuSCs) and fibro-adipogenic progenitors (FAPs). We demonstrate that administering active HGFA to animals is sufficient to induce G
in stem cells throughout the body and to significantly accelerate the processes of stem cell activation and tissue repair. Our data suggest that factors that induce G
will have broad therapeutic applications for regenerative medicine and wound healing.</abstract><cop>United States</cop><pmid>28423312</pmid><doi>10.1016/j.celrep.2017.03.066</doi></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 2211-1247 |
| ispartof | Cell reports (Cambridge), 2017-04, Vol.19 (3), p.479 |
| issn | 2211-1247 |
| language | eng |
| recordid | cdi_pubmed_primary_28423312 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adipocytes - cytology Adipocytes - drug effects Adipogenesis - drug effects Animals Cell Cycle - drug effects Fibroblasts - cytology Fibroblasts - drug effects Kinetics Mice, Inbred C57BL Mice, Knockout Muscle, Skeletal - cytology Serine Endopeptidases - administration & dosage Serine Endopeptidases - pharmacology Serum - metabolism Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Wound Healing - drug effects |
| title | HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G Alert |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T19%3A25%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HGFA%20Is%20an%20Injury-Regulated%20Systemic%20Factor%20that%20Induces%20the%20Transition%20of%20Stem%20Cells%20into%20G%20Alert&rft.jtitle=Cell%20reports%20(Cambridge)&rft.au=Rodgers,%20Joseph%20T&rft.date=2017-04-18&rft.volume=19&rft.issue=3&rft.spage=479&rft.pages=479-&rft.eissn=2211-1247&rft_id=info:doi/10.1016/j.celrep.2017.03.066&rft_dat=%3Cpubmed%3E28423312%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/28423312&rfr_iscdi=true |