HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G Alert
The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into G , a cellular state in which they have an increased functional ability to activate and participate in tissue repair...
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Veröffentlicht in: | Cell reports (Cambridge) 2017-04, Vol.19 (3), p.479 |
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Sprache: | eng |
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Zusammenfassung: | The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into G
, a cellular state in which they have an increased functional ability to activate and participate in tissue repair. However, the precise molecular signals that induce G
in stem cells have remained elusive. Here, we show that the injury-induced regulation of hepatocyte growth factor (HGF) proteolytic processing via the systemic protease, hepatocyte growth factor activator (HGFA), stimulates G
in skeletal muscle stem cells (MuSCs) and fibro-adipogenic progenitors (FAPs). We demonstrate that administering active HGFA to animals is sufficient to induce G
in stem cells throughout the body and to significantly accelerate the processes of stem cell activation and tissue repair. Our data suggest that factors that induce G
will have broad therapeutic applications for regenerative medicine and wound healing. |
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ISSN: | 2211-1247 |