Cardiac Changes and Their Association with Fetuin-A and Fibroblast Growth Factor-23 in Children with Chronic Kidney Disease

Aims: In children with chronic kidney disease (CKD), fetuin-A and fibroblast growth factor-23 (FGF-23) have been implicated in the mechanism and progression of several cardiac changes. This study aimed to determine the types and rates of cardiac changes in children with CKD and their association wit...

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Veröffentlicht in:	Nephron (2015) 2017-01, Vol.136 (3), p.233-242
Hauptverfasser:	Mudi, Abdullahi, Ntsinjana, Hopewell, Dickens, Caroline, Levy, Cecil, Ballot, Daynia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent alpha-2-HS-Glycoprotein - metabolism Child Child, Preschool Clinical Practice: Original Paper Cross-Sectional Studies Echocardiography Female Fibroblast Growth Factors - blood Heart - diagnostic imaging Heart - physiopathology Heart Function Tests Humans Hypertrophy, Left Ventricular - blood Hypertrophy, Left Ventricular - complications Hypertrophy, Left Ventricular - physiopathology Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Kidney Failure, Chronic - physiopathology Male
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Zusammenfassung:	Aims: In children with chronic kidney disease (CKD), fetuin-A and fibroblast growth factor-23 (FGF-23) have been implicated in the mechanism and progression of several cardiac changes. This study aimed to determine the types and rates of cardiac changes in children with CKD and their association with fetuin-A, FGF-23, and other cardiovascular risk factors (CVRFs). Methods: This comparative cross-sectional study recruited 88 children (5-18 years): 27 CKD I with a glomerular filtration rate (GFR) >90 mL/min/1.73 m 2 and 61 with a GFR of
ISSN:	1660-8151 2235-3186
DOI:	10.1159/000470858