Nonalcoholic Steatohepatitis

Nonalcoholic Steatohepatitis

Nonalcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worldwide. NASH is strongly associated with obesity and the metabolic syndrome, conditions that cause lipid accumulation in hepatocytes (hepatic steatosis). It is not well understood why some, but not...

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Veröffentlicht in:Annual review of medicine 2017-01, Vol.68 (1), p.85-98
Hauptverfasser: Suzuki, Ayako, Diehl, Anna Mae
Format: Artikel
Sprache:eng
Schlagworte:
adaptive mechanisms
Cell Death
hepatic fibrosis
Hepatitis - etiology
hepatocyte damage
Hepatocytes - pathology
Hepatocytes - physiology
Humans
Lipid Metabolism
lipotoxicity
Liver - metabolism
Liver - pathology
Liver Cirrhosis - etiology
Liver diseases
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - metabolism
Non-alcoholic Fatty Liver Disease - pathology
nonalcoholic fatty liver disease
Obesity
Pathogenesis
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Zusammenfassung:Nonalcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worldwide. NASH is strongly associated with obesity and the metabolic syndrome, conditions that cause lipid accumulation in hepatocytes (hepatic steatosis). It is not well understood why some, but not other, individuals with hepatic steatosis develop NASH. The factors that determine whether or not NASH progresses to cirrhosis are also unclear. This review summarizes key components of NASH pathogenesis and discusses how inherent and acquired variations in regulation of these processes impact the risk for NASH and NASH cirrhosis.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev-med-051215-031109