Synthesis and deposition of a Tröger's base polymer on the electrode surface for potentiometric detection of a neuroblastoma tumor marker metabolite

The development of novel diagnostic tools is a primary goal in bioanalytical chemistry. Here we report the synthesis of Tröger's base functionalized with amino- and coumarin-units designed as a monomeric unit for the development of an electrochemical cancer sensor. The synthesized receptor was deposited onto a conducting support using electrochemical polymerization, characterized spectroscopically and tested potentiometrically towards metabolites used as tumor markers of neuroblastoma. We propose an innovative approach to detect a low molecular weight metabolite of neuroblastoma.