Aptamer-based fiber sensor for thrombin detection

Aptamer-based fiber sensor for thrombin detection

The detection of thrombin based on aptamer binding is studied using two different optical fiber-based configurations: long period gratings coated with a thin layer of titanium dioxide and surface plasmon resonance devices in optical fibers coated with a multilayer of gold and titanium dioxide. These...

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Veröffentlicht in:Journal of biomedical optics 2016-08, Vol.21 (8), p.087005-087005
Hauptverfasser: Coelho, Luís, Marques Martins de Almeida, José Manuel, Santos, José Luís, da Silva Jorge, Pedro Alberto, Martins, Maria Cristina L, Viegas, Diana, Queirós, Raquel B
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container_end_page 087005
container_issue 8
container_start_page 087005
container_title Journal of biomedical optics
container_volume 21
creator Coelho, Luís
Marques Martins de Almeida, José Manuel
Santos, José Luís
da Silva Jorge, Pedro Alberto
Martins, Maria Cristina L
Viegas, Diana
Queirós, Raquel B
description The detection of thrombin based on aptamer binding is studied using two different optical fiber-based configurations: long period gratings coated with a thin layer of titanium dioxide and surface plasmon resonance devices in optical fibers coated with a multilayer of gold and titanium dioxide. These structures are functionalized and the performance to detect thrombin in the range 10 to 100 nM is compared in transmission mode. The sensitivity to the surrounding refractive index (RI) of the plasmonic device is higher than 3100  nm RIU−1 in the RI range 1.335 to 1.355, a factor of 20 greater than the sensitivity of the coated grating. The detection of 10 nM of thrombin was accomplished with a wavelength shift of 3.5 nm and a resolution of 0.54 nM.
doi_str_mv 10.1117/1.JBO.21.8.087005
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title Aptamer-based fiber sensor for thrombin detection
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