Preparation of benznidazole pellets for immediate drug delivery using the extrusion spheronization technique

Recent advances in the treatment of Chagas disease have followed combinations of drugs that act synergistically against infection, predominantly including benznidazole (BNZ) and azoles derivatives. Possible incompatibilities between these drugs, slow dissolution of BNZ and dose adjustment difficulti...

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Veröffentlicht in:	Drug development and industrial pharmacy 2017-05, Vol.43 (5), p.762-769
Hauptverfasser:	Alves-Silva, Ihatanderson, Marreto, Ricardo N., Gelfuso, Guilherme M., Sá-Barreto, Lívia C. L., Lima, Eliana M., Cunha-Filho, Marcílio S. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benznidazole Carboxymethylcellulose Sodium - chemistry Cellulose - chemistry Chagas disease Chemistry, Pharmaceutical - methods disintegrating agent dissolution Drug Compounding - methods Drug Delivery Systems - methods Drug Implants - chemistry Excipients - chemistry mixture design Nitroimidazoles - chemistry pellets Polyethylene Glycols - chemistry Polymethacrylic Acids - chemistry Solubility Starch - analogs & derivatives Starch - chemistry
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