Regulation of transcription factors via natural decoys in genomic DNA
Eukaryotic genomic DNA contains numerous high-affinity sites for transcription factors. Only a small fraction of these sites directly regulates target genes. Other high-affinity sites can serve as naturally present decoys that sequester transcription factors. Such natural decoys in genomic DNA may p...
Gespeichert in:
| Veröffentlicht in: | Transcription 2016-08, Vol.7 (4), p.115-120 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 120 |
|---|---|
| container_issue | 4 |
| container_start_page | 115 |
| container_title | Transcription |
| container_volume | 7 |
| creator | Kemme, Catherine A. Nguyen, Dan Chattopadhyay, Abhijnan Iwahara, Junji |
| description | Eukaryotic genomic DNA contains numerous high-affinity sites for transcription factors. Only a small fraction of these sites directly regulates target genes. Other high-affinity sites can serve as naturally present decoys that sequester transcription factors. Such natural decoys in genomic DNA may provide novel regulatory mechanisms for transcription factors. |
| doi_str_mv | 10.1080/21541264.2016.1188873 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_27384377</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1809602439</sourcerecordid><originalsourceid>FETCH-LOGICAL-c564t-1cab00c6637f86e16ecc68670f5fc238fded8a05e28544f9628d669998e45f593</originalsourceid><addsrcrecordid>eNp9UctOwzAQtBCIVqWfAMqRS4tfcZwLoirlIVUgIThbrmMXo8QudlLUvyehD8GFvexqd3ZmtQPAOYJjBDm8wiilCDM6xhCxMUKc84wcgX7XHyGc4eNDzWgPDGP8gG1QmkFCTkEPZ4RTkmV9MHvRy6aUtfUu8Sapg3RRBbv6aRipah9isrYycbJugiyTQiu_iYl1yVI7X1mV3D5NzsCJkWXUw10egLe72ev0YTR_vn-cTuYjlTJaj5CSCwgVYyQznGnEtFKMswya1ChMuCl0wSVMNeYppSZnmBeM5XnONU1NmpMBuN7yrppFpQulXXtwKVbBVjJshJdW_J04-y6Wfi1ozinjuCW43BEE_9noWIvKRqXLUjrtmygQhzmDmJJOK91CVfAxBm0OMgiKzgWxd0F0LoidC-3exe8bD1v7n7eAmy3AOuNDJb98KAtRy03pg2n_r2wU5H-Nb30slvI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1809602439</pqid></control><display><type>article</type><title>Regulation of transcription factors via natural decoys in genomic DNA</title><source>MEDLINE</source><source>PubMed Central</source><creator>Kemme, Catherine A. ; Nguyen, Dan ; Chattopadhyay, Abhijnan ; Iwahara, Junji</creator><creatorcontrib>Kemme, Catherine A. ; Nguyen, Dan ; Chattopadhyay, Abhijnan ; Iwahara, Junji</creatorcontrib><description>Eukaryotic genomic DNA contains numerous high-affinity sites for transcription factors. Only a small fraction of these sites directly regulates target genes. Other high-affinity sites can serve as naturally present decoys that sequester transcription factors. Such natural decoys in genomic DNA may provide novel regulatory mechanisms for transcription factors.</description><identifier>ISSN: 2154-1264</identifier><identifier>EISSN: 2154-1272</identifier><identifier>DOI: 10.1080/21541264.2016.1188873</identifier><identifier>PMID: 27384377</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Animals ; Binding Sites ; Chromatin - genetics ; Chromatin - metabolism ; Chromatin Assembly and Disassembly ; decoy ; DNA - genetics ; DNA - metabolism ; DNA Methylation ; Gene Expression Regulation ; Genome ; Humans ; Point-of-View ; Protein Binding ; regulatory elements ; Regulatory Sequences, Nucleic Acid ; sequestration ; target search ; transcription factors ; Transcription Factors - metabolism</subject><ispartof>Transcription, 2016-08, Vol.7 (4), p.115-120</ispartof><rights>2016 Taylor & Francis 2016</rights><rights>2016 Taylor & Francis 2016 Taylor & Francis</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-1cab00c6637f86e16ecc68670f5fc238fded8a05e28544f9628d669998e45f593</citedby><cites>FETCH-LOGICAL-c564t-1cab00c6637f86e16ecc68670f5fc238fded8a05e28544f9628d669998e45f593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984682/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984682/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27384377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kemme, Catherine A.</creatorcontrib><creatorcontrib>Nguyen, Dan</creatorcontrib><creatorcontrib>Chattopadhyay, Abhijnan</creatorcontrib><creatorcontrib>Iwahara, Junji</creatorcontrib><title>Regulation of transcription factors via natural decoys in genomic DNA</title><title>Transcription</title><addtitle>Transcription</addtitle><description>Eukaryotic genomic DNA contains numerous high-affinity sites for transcription factors. Only a small fraction of these sites directly regulates target genes. Other high-affinity sites can serve as naturally present decoys that sequester transcription factors. Such natural decoys in genomic DNA may provide novel regulatory mechanisms for transcription factors.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>Chromatin - genetics</subject><subject>Chromatin - metabolism</subject><subject>Chromatin Assembly and Disassembly</subject><subject>decoy</subject><subject>DNA - genetics</subject><subject>DNA - metabolism</subject><subject>DNA Methylation</subject><subject>Gene Expression Regulation</subject><subject>Genome</subject><subject>Humans</subject><subject>Point-of-View</subject><subject>Protein Binding</subject><subject>regulatory elements</subject><subject>Regulatory Sequences, Nucleic Acid</subject><subject>sequestration</subject><subject>target search</subject><subject>transcription factors</subject><subject>Transcription Factors - metabolism</subject><issn>2154-1264</issn><issn>2154-1272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UctOwzAQtBCIVqWfAMqRS4tfcZwLoirlIVUgIThbrmMXo8QudlLUvyehD8GFvexqd3ZmtQPAOYJjBDm8wiilCDM6xhCxMUKc84wcgX7XHyGc4eNDzWgPDGP8gG1QmkFCTkEPZ4RTkmV9MHvRy6aUtfUu8Sapg3RRBbv6aRipah9isrYycbJugiyTQiu_iYl1yVI7X1mV3D5NzsCJkWXUw10egLe72ev0YTR_vn-cTuYjlTJaj5CSCwgVYyQznGnEtFKMswya1ChMuCl0wSVMNeYppSZnmBeM5XnONU1NmpMBuN7yrppFpQulXXtwKVbBVjJshJdW_J04-y6Wfi1ozinjuCW43BEE_9noWIvKRqXLUjrtmygQhzmDmJJOK91CVfAxBm0OMgiKzgWxd0F0LoidC-3exe8bD1v7n7eAmy3AOuNDJb98KAtRy03pg2n_r2wU5H-Nb30slvI</recordid><startdate>20160807</startdate><enddate>20160807</enddate><creator>Kemme, Catherine A.</creator><creator>Nguyen, Dan</creator><creator>Chattopadhyay, Abhijnan</creator><creator>Iwahara, Junji</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160807</creationdate><title>Regulation of transcription factors via natural decoys in genomic DNA</title><author>Kemme, Catherine A. ; Nguyen, Dan ; Chattopadhyay, Abhijnan ; Iwahara, Junji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-1cab00c6637f86e16ecc68670f5fc238fded8a05e28544f9628d669998e45f593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Binding Sites</topic><topic>Chromatin - genetics</topic><topic>Chromatin - metabolism</topic><topic>Chromatin Assembly and Disassembly</topic><topic>decoy</topic><topic>DNA - genetics</topic><topic>DNA - metabolism</topic><topic>DNA Methylation</topic><topic>Gene Expression Regulation</topic><topic>Genome</topic><topic>Humans</topic><topic>Point-of-View</topic><topic>Protein Binding</topic><topic>regulatory elements</topic><topic>Regulatory Sequences, Nucleic Acid</topic><topic>sequestration</topic><topic>target search</topic><topic>transcription factors</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kemme, Catherine A.</creatorcontrib><creatorcontrib>Nguyen, Dan</creatorcontrib><creatorcontrib>Chattopadhyay, Abhijnan</creatorcontrib><creatorcontrib>Iwahara, Junji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Transcription</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kemme, Catherine A.</au><au>Nguyen, Dan</au><au>Chattopadhyay, Abhijnan</au><au>Iwahara, Junji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of transcription factors via natural decoys in genomic DNA</atitle><jtitle>Transcription</jtitle><addtitle>Transcription</addtitle><date>2016-08-07</date><risdate>2016</risdate><volume>7</volume><issue>4</issue><spage>115</spage><epage>120</epage><pages>115-120</pages><issn>2154-1264</issn><eissn>2154-1272</eissn><abstract>Eukaryotic genomic DNA contains numerous high-affinity sites for transcription factors. Only a small fraction of these sites directly regulates target genes. Other high-affinity sites can serve as naturally present decoys that sequester transcription factors. Such natural decoys in genomic DNA may provide novel regulatory mechanisms for transcription factors.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>27384377</pmid><doi>10.1080/21541264.2016.1188873</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2154-1264 |
| ispartof | Transcription, 2016-08, Vol.7 (4), p.115-120 |
| issn | 2154-1264 2154-1272 |
| language | eng |
| recordid | cdi_pubmed_primary_27384377 |
| source | MEDLINE; PubMed Central |
| subjects | Animals Binding Sites Chromatin - genetics Chromatin - metabolism Chromatin Assembly and Disassembly decoy DNA - genetics DNA - metabolism DNA Methylation Gene Expression Regulation Genome Humans Point-of-View Protein Binding regulatory elements Regulatory Sequences, Nucleic Acid sequestration target search transcription factors Transcription Factors - metabolism |
| title | Regulation of transcription factors via natural decoys in genomic DNA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T02%3A19%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regulation%20of%20transcription%20factors%20via%20natural%20decoys%20in%20genomic%20DNA&rft.jtitle=Transcription&rft.au=Kemme,%20Catherine%20A.&rft.date=2016-08-07&rft.volume=7&rft.issue=4&rft.spage=115&rft.epage=120&rft.pages=115-120&rft.issn=2154-1264&rft.eissn=2154-1272&rft_id=info:doi/10.1080/21541264.2016.1188873&rft_dat=%3Cproquest_pubme%3E1809602439%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1809602439&rft_id=info:pmid/27384377&rfr_iscdi=true |