Regulation of transcription factors via natural decoys in genomic DNA

Regulation of transcription factors via natural decoys in genomic DNA

Eukaryotic genomic DNA contains numerous high-affinity sites for transcription factors. Only a small fraction of these sites directly regulates target genes. Other high-affinity sites can serve as naturally present decoys that sequester transcription factors. Such natural decoys in genomic DNA may p...

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Veröffentlicht in:Transcription 2016-08, Vol.7 (4), p.115-120
Hauptverfasser: Kemme, Catherine A., Nguyen, Dan, Chattopadhyay, Abhijnan, Iwahara, Junji
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Binding Sites
Chromatin - genetics
Chromatin - metabolism
Chromatin Assembly and Disassembly
decoy
DNA - genetics
DNA - metabolism
DNA Methylation
Gene Expression Regulation
Genome
Humans
Point-of-View
Protein Binding
regulatory elements
Regulatory Sequences, Nucleic Acid
sequestration
target search
transcription factors
Transcription Factors - metabolism
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Beschreibung
Zusammenfassung:Eukaryotic genomic DNA contains numerous high-affinity sites for transcription factors. Only a small fraction of these sites directly regulates target genes. Other high-affinity sites can serve as naturally present decoys that sequester transcription factors. Such natural decoys in genomic DNA may provide novel regulatory mechanisms for transcription factors.
ISSN:2154-1264
2154-1272
DOI:10.1080/21541264.2016.1188873