Determination of continuous complex refractive index dispersion of biotissue based on internal reflection
The complex refractive index dispersion (CRID), which contains the information on the refractive index dispersion and extinction coefficient spectra, is an important optical parameter of biotissue. However, it is hard to perform the CRID measurement on biotissues due to their high scattering propert...
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| Veröffentlicht in: | Journal of biomedical optics 2016-01, Vol.21 (1), p.015003-015003 |
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| container_title | Journal of biomedical optics |
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| creator | Deng, Zhichao Wang, Jin Ye, Qing Sun, Tengqian Zhou, Wenyuan Mei, Jianchun Zhang, Chunping Tian, Jianguo |
| description | The complex refractive index dispersion (CRID), which contains the information on the refractive index dispersion and extinction coefficient spectra, is an important optical parameter of biotissue. However, it is hard to perform the CRID measurement on biotissues due to their high scattering property. Continuous CRID measurement based on internal reflection (CCRIDM-IR) is introduced. By using a lab-made apparatus, internal reflectance spectra of biotissue samples at multiple incident angles were detected, from which the continuous CRIDs were calculated based on the Fresnel formula. Results showed that in 400- to 750-nm range, hemoglobin solution has complicated dispersion and extinction coefficient spectra, while other biotissues have normal dispersion properties, and their extinction coefficients do not vary much with different wavelengths. The normal dispersion can be accurately described by several coefficients of dispersion equations (Cauchy equation, Cornu equation, and Conrady equation). To our knowledge, this is the first time that the continuous CRID of scattering biotissue over a continuous spectral region is measured, and we hereby have proven that CCRIDM-IR is a good method for continuous CRID research of biotissue. |
| doi_str_mv | 10.1117/1.JBO.21.1.015003 |
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However, it is hard to perform the CRID measurement on biotissues due to their high scattering property. Continuous CRID measurement based on internal reflection (CCRIDM-IR) is introduced. By using a lab-made apparatus, internal reflectance spectra of biotissue samples at multiple incident angles were detected, from which the continuous CRIDs were calculated based on the Fresnel formula. Results showed that in 400- to 750-nm range, hemoglobin solution has complicated dispersion and extinction coefficient spectra, while other biotissues have normal dispersion properties, and their extinction coefficients do not vary much with different wavelengths. The normal dispersion can be accurately described by several coefficients of dispersion equations (Cauchy equation, Cornu equation, and Conrady equation). To our knowledge, this is the first time that the continuous CRID of scattering biotissue over a continuous spectral region is measured, and we hereby have proven that CCRIDM-IR is a good method for continuous CRID research of biotissue.</description><identifier>ISSN: 1083-3668</identifier><identifier>EISSN: 1560-2281</identifier><identifier>DOI: 10.1117/1.JBO.21.1.015003</identifier><identifier>PMID: 26757024</identifier><language>eng</language><publisher>United States: Society of Photo-Optical Instrumentation Engineers</publisher><subject>Adipose Tissue - chemistry ; Animals ; Cattle ; Chickens ; Coefficients ; Dispersions ; Equipment Design ; Extinction ; Liver - chemistry ; Mathematical analysis ; Models, Biological ; Muscles - chemistry ; Optics and Photonics - instrumentation ; Reflection ; Refractive index ; Refractivity ; Refractometry - instrumentation ; Refractometry - methods ; Research Papers: General ; Spectra ; Swine</subject><ispartof>Journal of biomedical optics, 2016-01, Vol.21 (1), p.015003-015003</ispartof><rights>2016 Society of Photo-Optical Instrumentation Engineers (SPIE)</rights><rights>2016 Society of Photo-Optical Instrumentation Engineers (SPIE) 2016 Society of Photo-Optical Instrumentation Engineers</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-f2c00617e10519ced8321871dd5b48c1b2eb25e94b3600404f2f0112787c12483</citedby><cites>FETCH-LOGICAL-c505t-f2c00617e10519ced8321871dd5b48c1b2eb25e94b3600404f2f0112787c12483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707208/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707208/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26757024$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Zhichao</creatorcontrib><creatorcontrib>Wang, Jin</creatorcontrib><creatorcontrib>Ye, Qing</creatorcontrib><creatorcontrib>Sun, Tengqian</creatorcontrib><creatorcontrib>Zhou, Wenyuan</creatorcontrib><creatorcontrib>Mei, Jianchun</creatorcontrib><creatorcontrib>Zhang, Chunping</creatorcontrib><creatorcontrib>Tian, Jianguo</creatorcontrib><title>Determination of continuous complex refractive index dispersion of biotissue based on internal reflection</title><title>Journal of biomedical optics</title><addtitle>J. Biomed. Opt</addtitle><description>The complex refractive index dispersion (CRID), which contains the information on the refractive index dispersion and extinction coefficient spectra, is an important optical parameter of biotissue. However, it is hard to perform the CRID measurement on biotissues due to their high scattering property. Continuous CRID measurement based on internal reflection (CCRIDM-IR) is introduced. By using a lab-made apparatus, internal reflectance spectra of biotissue samples at multiple incident angles were detected, from which the continuous CRIDs were calculated based on the Fresnel formula. Results showed that in 400- to 750-nm range, hemoglobin solution has complicated dispersion and extinction coefficient spectra, while other biotissues have normal dispersion properties, and their extinction coefficients do not vary much with different wavelengths. The normal dispersion can be accurately described by several coefficients of dispersion equations (Cauchy equation, Cornu equation, and Conrady equation). To our knowledge, this is the first time that the continuous CRID of scattering biotissue over a continuous spectral region is measured, and we hereby have proven that CCRIDM-IR is a good method for continuous CRID research of biotissue.</description><subject>Adipose Tissue - chemistry</subject><subject>Animals</subject><subject>Cattle</subject><subject>Chickens</subject><subject>Coefficients</subject><subject>Dispersions</subject><subject>Equipment Design</subject><subject>Extinction</subject><subject>Liver - chemistry</subject><subject>Mathematical analysis</subject><subject>Models, Biological</subject><subject>Muscles - chemistry</subject><subject>Optics and Photonics - instrumentation</subject><subject>Reflection</subject><subject>Refractive index</subject><subject>Refractivity</subject><subject>Refractometry - instrumentation</subject><subject>Refractometry - methods</subject><subject>Research Papers: General</subject><subject>Spectra</subject><subject>Swine</subject><issn>1083-3668</issn><issn>1560-2281</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1TAQhSMEoqXwAGxQlmwSZpzE9t0glZbyo0plUdZW4kzAVWIH26mAp8fhXq5aqCpWHs1858gzJ8ueI5SIKF5h-fHNRcmwxBKwAageZIfYcCgYk_gw1SCrouJcHmRPQrgCAMk3_HF2wLhoBLD6MDOnFMlPxrbROJu7IdfORmMXt4RUTvNI33NPg291NNeUG9unRm_CTD7sFJ1x0YSwUN61gfo8dY1NrrYdV-lIevV-mj0a2jHQs917lH0-e3t58r44v3j34eT4vNANNLEYmAbgKAihwY2mXlYMpcC-b7paauwYdayhTd1VHKCGemADIDIhhUZWy-ooe731nZduol6Tjb4d1ezN1PofyrVG3Z5Y81V9cdeqFiAYrAYvdwbefVsoRDWZoGkcW0vpKgqF5IljNfsPlINsNmmdhOIW1d6FkM6y_xGCWtNUqFKaimEqtmkmzYubq-wVf-JLQLkFwmxIXbllvXm41_HyLsEe-2nmvzW_e8c-Gj3Sp9Ozf8ZzP1S_ABLOxhs</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Deng, Zhichao</creator><creator>Wang, Jin</creator><creator>Ye, Qing</creator><creator>Sun, Tengqian</creator><creator>Zhou, Wenyuan</creator><creator>Mei, Jianchun</creator><creator>Zhang, Chunping</creator><creator>Tian, Jianguo</creator><general>Society of Photo-Optical Instrumentation Engineers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Determination of continuous complex refractive index dispersion of biotissue based on internal reflection</title><author>Deng, Zhichao ; Wang, Jin ; Ye, Qing ; Sun, Tengqian ; Zhou, Wenyuan ; Mei, Jianchun ; Zhang, Chunping ; Tian, Jianguo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-f2c00617e10519ced8321871dd5b48c1b2eb25e94b3600404f2f0112787c12483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adipose Tissue - chemistry</topic><topic>Animals</topic><topic>Cattle</topic><topic>Chickens</topic><topic>Coefficients</topic><topic>Dispersions</topic><topic>Equipment Design</topic><topic>Extinction</topic><topic>Liver - chemistry</topic><topic>Mathematical analysis</topic><topic>Models, Biological</topic><topic>Muscles - chemistry</topic><topic>Optics and Photonics - instrumentation</topic><topic>Reflection</topic><topic>Refractive index</topic><topic>Refractivity</topic><topic>Refractometry - instrumentation</topic><topic>Refractometry - methods</topic><topic>Research Papers: General</topic><topic>Spectra</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, Zhichao</creatorcontrib><creatorcontrib>Wang, Jin</creatorcontrib><creatorcontrib>Ye, Qing</creatorcontrib><creatorcontrib>Sun, Tengqian</creatorcontrib><creatorcontrib>Zhou, Wenyuan</creatorcontrib><creatorcontrib>Mei, Jianchun</creatorcontrib><creatorcontrib>Zhang, Chunping</creatorcontrib><creatorcontrib>Tian, Jianguo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biomedical optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Zhichao</au><au>Wang, Jin</au><au>Ye, Qing</au><au>Sun, Tengqian</au><au>Zhou, Wenyuan</au><au>Mei, Jianchun</au><au>Zhang, Chunping</au><au>Tian, Jianguo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of continuous complex refractive index dispersion of biotissue based on internal reflection</atitle><jtitle>Journal of biomedical optics</jtitle><addtitle>J. Biomed. Opt</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>21</volume><issue>1</issue><spage>015003</spage><epage>015003</epage><pages>015003-015003</pages><issn>1083-3668</issn><eissn>1560-2281</eissn><abstract>The complex refractive index dispersion (CRID), which contains the information on the refractive index dispersion and extinction coefficient spectra, is an important optical parameter of biotissue. However, it is hard to perform the CRID measurement on biotissues due to their high scattering property. Continuous CRID measurement based on internal reflection (CCRIDM-IR) is introduced. By using a lab-made apparatus, internal reflectance spectra of biotissue samples at multiple incident angles were detected, from which the continuous CRIDs were calculated based on the Fresnel formula. Results showed that in 400- to 750-nm range, hemoglobin solution has complicated dispersion and extinction coefficient spectra, while other biotissues have normal dispersion properties, and their extinction coefficients do not vary much with different wavelengths. The normal dispersion can be accurately described by several coefficients of dispersion equations (Cauchy equation, Cornu equation, and Conrady equation). To our knowledge, this is the first time that the continuous CRID of scattering biotissue over a continuous spectral region is measured, and we hereby have proven that CCRIDM-IR is a good method for continuous CRID research of biotissue.</abstract><cop>United States</cop><pub>Society of Photo-Optical Instrumentation Engineers</pub><pmid>26757024</pmid><doi>10.1117/1.JBO.21.1.015003</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose Tissue - chemistry Animals Cattle Chickens Coefficients Dispersions Equipment Design Extinction Liver - chemistry Mathematical analysis Models, Biological Muscles - chemistry Optics and Photonics - instrumentation Reflection Refractive index Refractivity Refractometry - instrumentation Refractometry - methods Research Papers: General Spectra Swine |
| title | Determination of continuous complex refractive index dispersion of biotissue based on internal reflection |
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