[(11)C]CO2 to [(11)C]CO conversion mediated by [(11)C]silanes: a novel route for [(11)C]carbonylation reactions

A novel chemical methodology is described for the conversion of [(11)C]CO2 to [(11)C]CO. Diphenylmethyl silanes trap [(11)C]CO2 and release [(11)C]CO rapidly when triggered by TBAF. Released [(11)C]CO was used to produce [(11)C]N-benzylbenzamide and AMPA receptor ligand, [(11)C], in radiochemical yi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-07, Vol.51 (59), p.11795
Hauptverfasser:	Taddei, Carlotta, Bongarzone, Salvatore, Haji Dheere, Abdul Karim, Gee, Antony D
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon Dioxide - chemistry Carbon Monoxide - chemistry Carbon Radioisotopes Molecular Structure Silanes - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A novel chemical methodology is described for the conversion of [(11)C]CO2 to [(11)C]CO. Diphenylmethyl silanes trap [(11)C]CO2 and release [(11)C]CO rapidly when triggered by TBAF. Released [(11)C]CO was used to produce [(11)C]N-benzylbenzamide and AMPA receptor ligand, [(11)C], in radiochemical yields >90% within 6 min from [(11)C]CO2 production.
ISSN:	1364-548X
DOI:	10.1039/c5cc02095f