Immunotherapy of metastatic and autochthonous liver cancer with IL-15/IL-15Rα fusion protein

Liver cancer has a poor prognosis. Our recent study demonstrates that hyper-IL-15, composed of IL-15 and the sushi domain of IL-15 receptor α chain, provides an effective therapy against well-established metastatic and autochthonous liver cancers in mouse models by triggering activation and expansio...

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Veröffentlicht in:	Oncoimmunology 2014-11, Vol.3 (11), p.e963409-e963409
Hauptverfasser:	Cheng, Liang, Du, Xuexiang, Su, Lishan, Wang, Shengdian
Format:	Artikel
Sprache:	eng
Schlagworte:	Author's View CD8 hyper-IL-15 IFNγ immunotherapy liver cancer T cell
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Liver cancer has a poor prognosis. Our recent study demonstrates that hyper-IL-15, composed of IL-15 and the sushi domain of IL-15 receptor α chain, provides an effective therapy against well-established metastatic and autochthonous liver cancers in mouse models by triggering activation and expansion of hepatic CD8 + T cells.
ISSN:	2162-4011 2162-402X 2162-402X
DOI:	10.4161/21624011.2014.963409