Rapid Blood Pressure Lowering According to Recovery at Different Time Intervals after Acute Intracerebral Hemorrhage: Pooled Analysis of the INTERACT Studies

Rapid Blood Pressure Lowering According to Recovery at Different Time Intervals after Acute Intracerebral Hemorrhage: Pooled Analysis of the INTERACT Studies

Background and Purpose: Early intensive blood pressure (BP) lowering has been shown to improve functional outcome in acute intracerebral hemorrhage (ICH), but the treatment effect is modest and without a clearly defined underlying explanatory mechanism. We aimed at more reliably quantifying the bene...

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Veröffentlicht in:Cerebrovascular diseases (Basel, Switzerland) Switzerland), 2015-01, Vol.39 (3-4), p.242-248
Hauptverfasser: Wang, Xia, Arima, Hisatomi, Al-Shahi Salman, Rustam, Woodward, Mark, Heeley, Emma, Stapf, Christian, Lavados, Pablo M., Robinson, Thompson, Huang, Yining, Wang, Jiguang, Delcourt, Candice, Anderson, Craig S.
Format: Artikel
Sprache:eng
Schlagworte:
Acute Disease
Adult
Aged
Aged, 80 and over
Analysis
Blood pressure
Blood Pressure - physiology
Cerebral Hemorrhage - complications
Cerebral Hemorrhage - therapy
Female
Humans
Hypotension - etiology
Hypotension - physiopathology
Intracerebral hemorrhage
Male
Middle Aged
Original Paper
Time Factors
Treatment Outcome
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Zusammenfassung:Background and Purpose: Early intensive blood pressure (BP) lowering has been shown to improve functional outcome in acute intracerebral hemorrhage (ICH), but the treatment effect is modest and without a clearly defined underlying explanatory mechanism. We aimed at more reliably quantifying the benefits of this treatment according to different time periods in the recovery of participants in the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT) studies. Methods: Pooled analysis of the pilot INTERACT1 (n = 404) and main INTERACT2 (n = 2,839) involving patients with spontaneous ICH (
ISSN:1015-9770
1421-9786
DOI:10.1159/000381107