Tip variant of focal segmental glomerulosclerosis: is it truly a benign variant?

Tip variant of focal segmental glomerulosclerosis: is it truly a benign variant?

Background: Even though frequently described as a benign entity, the outcomes of the tip variant of focal segmental glomerulosclerosis (FSGS) have proven to be unclear. Methods: This retrospective study includes a cohort of tip variant cases who presented to us from 2009 to 2012 and the analysis of...

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Veröffentlicht in:Renal failure 2015-05, Vol.37 (5), p.763-768
Hauptverfasser: Trivedi, Mayuri, Pasari, Amit, Chowdhury, Arpita Roy, Abraham, Anila, Pandey, Rajendra
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Biopsy
Creatinine - analysis
Female
Focal segmental glomerulosclerosis
Glomerulosclerosis, Focal Segmental - pathology
Humans
Immunosuppression
India
Male
Middle Aged
nephrotic syndrome
NOS variant
Prognosis
Proteinuria - epidemiology
Retrospective Studies
tip variant
Treatment Outcome
Young Adult
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Zusammenfassung:Background: Even though frequently described as a benign entity, the outcomes of the tip variant of focal segmental glomerulosclerosis (FSGS) have proven to be unclear. Methods: This retrospective study includes a cohort of tip variant cases who presented to us from 2009 to 2012 and the analysis of their presenting clinical, histopathological features and treatment outcomes in comparison to the not otherwise specified (NOS) variants from our center in East India. Results: Of the 224 biopsies of primary FSGS, 30 cases were the tip variant (13.39%). The mean age of presentation was around 29 years, with 57% being males. A nephrotic presentation was seen in 87% of cases, with 20% showing a presentation at
ISSN:0886-022X
1525-6049
DOI:10.3109/0886022X.2015.1014755