Central Adrenal Insufficiency Could Not Be Confirmed by Measurement of Basal Serum DHEAS Levels in Pubertal Children

Central Adrenal Insufficiency Could Not Be Confirmed by Measurement of Basal Serum DHEAS Levels in Pubertal Children

Background: Central adrenal insufficiency (CAI) is due to a decrease of CRH and/or ACTH secretion. ACTH-dependent dehydroepiandrosterone sulphate (DHEAS) has been postulated as a possible marker of adrenal function in adult patients. Aims: To evaluate the usefulness of basal serum DHEAS determinatio...

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Veröffentlicht in:Hormone research in paediatrics 2014-01, Vol.82 (5), p.332-337
Hauptverfasser: Vaiani, Elisa, Maceiras, Mercedes, Chaler, Eduardo, Lazzati, Juan Manuel, Chiavero, M., Novelle, Claudia, Rivarola, Marco, Belgorosky, Alicia
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adrenal Insufficiency - blood
Adrenocorticotropic Hormone - blood
Adult
Biomarkers - blood
Child
Dehydroepiandrosterone - blood
Humans
Hydrocortisone - blood
Male
Original Paper
Puberty - blood
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Zusammenfassung:Background: Central adrenal insufficiency (CAI) is due to a decrease of CRH and/or ACTH secretion. ACTH-dependent dehydroepiandrosterone sulphate (DHEAS) has been postulated as a possible marker of adrenal function in adult patients. Aims: To evaluate the usefulness of basal serum DHEAS determination to diagnose CAI in pubertal patients with a suspected diagnosis of CAI. Methods: Ninety-four pubertal patients suspected of having CAI were divided into two groups according to sufficient (group 1) or insufficient (group 2) low-dose ACTH test serum cortisol response. Concordance with low (
ISSN:1663-2818
1663-2826
DOI:10.1159/000368318