Sex-Dependent Decrease of Sphingomyelinase Activity During Alcohol Withdrawal Treatment

Background: In vitro and in vivo studies have demonstrated the role of the acid sphingomyelinase (ASM) in pathophysiological processes and alterations in response to ethanol exposure. Cellular and plasmatic ASM activities are increased in male alcohol dependent patients and decrease during physical...

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Veröffentlicht in:	Cellular physiology and biochemistry 2014-01, Vol.34 (1), p.71-81
Hauptverfasser:	Mühle, Christiane, Amova, Violina, Biermann, Teresa, Bayerlein, Kristina, Richter-Schmidinger, Tanja, Kraus, Thomas, Reichel, Martin, Gulbins, Erich, Kornhuber, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid sphingomyelinase Adult Alcohol dependence Alcoholism - therapy Body Mass Index Craving Depression Female Gender Humans Male Middle Aged Original Paper Psychometrics Sex Factors Sphingomyelin Phosphodiesterase - blood Sphingomyelin Phosphodiesterase - metabolism Substance Withdrawal Syndrome - enzymology Substance Withdrawal Syndrome - physiopathology Surveys and Questionnaires Time Factors Withdrawal
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Zusammenfassung:	Background: In vitro and in vivo studies have demonstrated the role of the acid sphingomyelinase (ASM) in pathophysiological processes and alterations in response to ethanol exposure. Cellular and plasmatic ASM activities are increased in male alcohol dependent patients and decrease during physical withdrawal. Methods: Here, we analyzed the time course of ASM in male and also female acutely intoxicated patients during alcohol withdrawal and compared the activity levels to those under long-term maintenance treatment. Craving and further psychometric parameters were assessed by questionnaires. Results: The gradual decrease of serum ASM was confirmed in males (p
ISSN:	1015-8987 1421-9778
DOI:	10.1159/000362985