Anti hyperalgesic potentials of Laggera aurita in Swiss Albino mice

Anti hyperalgesic potentials of Laggera aurita in Swiss Albino mice

The ethnomedical uses of Laggera aurita (LA), including its anti-nociceptive properties have been documented in literature. This study evaluated the anti-hyperalgesic effects of the methanolic extract of LA (MELA) using chemically and mechanically induced hyperalgesia models. Acute toxicity and prel...

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Veröffentlicht in:Pakistan journal of pharmaceutical sciences 2014-01, Vol.27 (1), p.169
Hauptverfasser: Olurishe, Temidayo Olutoyin, Mati, Fatima Guiet
Format: Artikel
Sprache:eng
Schlagworte:
Analgesics - therapeutic use
Animals
Asteraceae - chemistry
Female
Hyperalgesia - drug therapy
Male
Mice
Phytotherapy
Plant Extracts - therapeutic use
Plant Extracts - toxicity
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Zusammenfassung:The ethnomedical uses of Laggera aurita (LA), including its anti-nociceptive properties have been documented in literature. This study evaluated the anti-hyperalgesic effects of the methanolic extract of LA (MELA) using chemically and mechanically induced hyperalgesia models. Acute toxicity and preliminary phytochemical screening were also conducted. The intraperitoneal median lethal dose was found to be 3807.88 mg/kg, while saponins, tannins and carbohydrates were found to be present in the plant material. MELA exhibited significant analgesic activity in the acetic acid induced writhing and Randall-Siletto tests. The 400 mg/kg dose of MELA exhibited a significant (p
ISSN:1011-601X