THE CYTOTOXICITY OF 5-FLUOROURACIL IS DUE TO ITS INCORPORATION INTO RNA NOT ITS INHIBITION OF THYMIDYLATE SYNTHASE AS EVIDENCED BY THE USE OF A MOUSE CELL MUTANT DEFICIENT IN THYMIDYLATE SYNTHASE

The biochemical basis for the cytotoxicity of 5-fluorouracil is still controversial; it is not clear whether the mechanism involves interference with DNA metabolism or incorporation of the drug into RNA. To distinguish between these two possibilities, we took advantage of a mutant strain of the mous...

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