Coexistence of familial Mediterranean fever and rheumatoid arthritis

Coexistence of familial Mediterranean fever and rheumatoid arthritis

Abstract Familial Mediterranean fever (FMF) is an autoinflammatory disorder characterized by recurrent febrile polyserositis and arthritis. Although accompanying seronegative spondyloarthropathy has been reported in FMF, coexistence with rheumatoid arthritis (RA) is very rare. This case report descr...

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Veröffentlicht in:Modern rheumatology 2014-01, Vol.24 (1), p.212-216
Hauptverfasser: Migita, Kiyoshi, Abiru, Seigo, Sasaki, Osamu, Miyashita, Taiichiro, Izumi, Yasumori, Nishino, Ayako, Jiuchi, Yuka, Kawakami, Atsushi, Yasunami, Michio
Format: Artikel
Sprache:eng
Schlagworte:
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - genetics
Colchicine
Colchicine - therapeutic use
Cytoskeletal Proteins - genetics
Familial Mediterranean fever
Familial Mediterranean Fever - complications
Familial Mediterranean Fever - drug therapy
Familial Mediterranean Fever - genetics
Female
Humans
MEFV gene
Middle Aged
Mutation
Pyrin
Rheumatic fever
Rheumatoid arthritis
Rheumatology
Treatment Outcome
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Zusammenfassung:Abstract Familial Mediterranean fever (FMF) is an autoinflammatory disorder characterized by recurrent febrile polyserositis and arthritis. Although accompanying seronegative spondyloarthropathy has been reported in FMF, coexistence with rheumatoid arthritis (RA) is very rare. This case report describes a Japanese female RA patient who presented with periodic fever. Genetic analysis revealed compound heterozygous mutations in exon 2 and 3 of the MEFV gene (E148Q/G304R/P369S/R408Q). The patient was successfully treated with colchicine with 3-year follow-up.
ISSN:1439-7595
1439-7609
DOI:10.3109/14397595.2013.852843