Lignan Glucosides from Sinomenium acutum Rhizomes

The new lignan glucoside, acutumoside (1), was isolated from Sinomenium acutum rhizomes together with nine known compounds (2-10). The structure of 1 was elucidated on the basis of extensive spectroscopic analyses, including two-dimensional nuclear magnetic resonance and chemical reactions. Compound...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2013, Vol.77 (10), p.2144-2147
Hauptverfasser:	KIM, Ki Hyun, MOON, Sae Rom, KIM, Chung Sub, WOO, Kyeong Wan, CHOI, Sang Un, LEE, Kang Ro
Format:	Artikel
Sprache:	eng
Schlagworte:	acutumoside Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects cytotoxicity Glucosides - chemistry Glucosides - isolation & purification Glucosides - pharmacology Humans lignan Lignans - chemistry Menispermaceae Rhizome - chemistry Sinomenium - chemistry Sinomenium acutum
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Zusammenfassung:	The new lignan glucoside, acutumoside (1), was isolated from Sinomenium acutum rhizomes together with nine known compounds (2-10). The structure of 1 was elucidated on the basis of extensive spectroscopic analyses, including two-dimensional nuclear magnetic resonance and chemical reactions. Compounds 2, 7, 8, and 10 displayed potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines, while compound 1 showed weak activity against these human tumor cells.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.130445