Radiolabeled antibodies : results and potential in cancer therapy

Radiolabeled antibodies are analyzed from the classical approach in radiation oncology being compared to geometric isotopic implants, external radiation, and tumor-dose response and energy of the isotope used for cytotoxicity. In addition, physiological factors that limit antibody uptake, varied rou...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1990-02, Vol.50 (3), p.1011s-1013s
Hauptverfasser:	ORDER, S. E, SLEEPER, A. M, STILLWAGON, G. B, KLEIN, J. L, LEICHNER, P. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neoplasm - immunology Biological and medical sciences Dose-Response Relationship, Radiation Humans Medical sciences Neoplasms - radiotherapy Radiation therapy and radiosensitizing agent Radioisotopes - administration & dosage Radiotherapy Dosage Treatment with physical agents Treatment. General aspects Tumors
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Beschreibung
Zusammenfassung:	Radiolabeled antibodies are analyzed from the classical approach in radiation oncology being compared to geometric isotopic implants, external radiation, and tumor-dose response and energy of the isotope used for cytotoxicity. In addition, physiological factors that limit antibody uptake, varied routes of administration, toxicity of treatment, as well as present clinical progress are reviewed.
ISSN:	0008-5472 1538-7445