Fluorescent organic nanocrystals and non-doped nanoparticles for biological applications

The recently developed fluorescent organic nanocrystals and non-doped nanoparticles (FONs) occupy a special position among other nanoparticle systems that are used for studying a variety of fundamental processes in the life sciences. Understanding their particular photophysical behavior allows proper design of FONs. The usual preparation methods are described. It is shown that FONs lead to original applications as biochemical sensors and biolabels for immunoassays. They also show high potentialities for bio-imaging of cell cultures, drug-delivery control, angiography and in vivo bio-imaging of solid tumors. FONs show high potentialities for biochemical sensing, cell staining, drug-delivery control, in vivo bio-imaging and nanomedicine.