A Hair Growth-Promoting Effect of Chinese Black Tea Extract in Mice

Chinese black tea extract (CBTE) fermented with Aspergillus sp. significantly promoted hair growth after 2 weeks of topical application in shaved 6 week-old male C3H/He mice. The hair growth-promoting effect of CBTE was potentiated synergistically by capsaicin, which has no effect on hair growth by...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2013, Vol.77 (7), p.1606-1607
Hauptverfasser:	HOU, I-Ching, OI, Yasuyuki, FUJITA, Hiroyuki, YANO, Yoshihisa, FUKAMI, Harukazu, YOSHIKAWA, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspergillus C3H/He mice capsaicin Chinese black tea extract (CBTE) estrogen receptor Hair - drug effects Hair - growth & development hair growth Male Mice Plant Extracts - pharmacology Tea - chemistry
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Zusammenfassung:	Chinese black tea extract (CBTE) fermented with Aspergillus sp. significantly promoted hair growth after 2 weeks of topical application in shaved 6 week-old male C3H/He mice. The hair growth-promoting effect of CBTE was potentiated synergistically by capsaicin, which has no effect on hair growth by itself. CBTE displayed an affinity for estrogen receptor (ER)α, with an IC 50 value of 74.8 µg/mL. This effect of CBTE might be mediated by the ERs, since a similar effect induced by orally administered soy isoflavone, a mixture of ERs ligands, has been reported to be synergistically potentiated by capsaicin.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.130298