Delineating the "galectin signature" of the tumor microenvironment

Delineating the "galectin signature" of the tumor microenvironment

Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a dynamically regulated 'galectin signature', which delineates the progression of prostate cancer, highlighting galectin-1 as an attracti...

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Veröffentlicht in:Oncoimmunology 2013-04, Vol.2 (4), p.e23565-e23565
Hauptverfasser: Compagno, Daniel, Laderach, Diego J., Gentilini, Lucas, Jaworski, Felipe M., Rabinovich, Gabriel A.
Format: Artikel
Sprache:eng
Schlagworte:
angiogenesis
Author's View
galectins
gene signature
metastasis
prostate cancer
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Zusammenfassung:Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a dynamically regulated 'galectin signature', which delineates the progression of prostate cancer, highlighting galectin-1 as an attractive target for anti-angiogenic therapy in advanced stages of the disease.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.23565