Hypothyroidism incidence and thyrotropin serum levels in newborns

congenital hypothyroidism is the third sub-clinic hereditary disease in Mexico. Infants with total or partial underactive thyroid gland presented at birth showed high levels of thyrotropin. This allows identifying patients at risk for developing it through screening tests. The aim was to determinate the incidence of neonatal congenital hypothyroidism in newborns in our hospital as well as set the cut-off value in screening test. samples from 4049 cord blood of newborns were processed. TSH was measurement by ELISA. Probands with high values subsequently underwent to confirmatory testing TSH micro-particle immunoassay. the results showed incidence of hypothyroidism of 1.2 per 1000 newborns. The cut-off value obtained in the screening test was 26.63 mUI/L. TSH values showed a different distribution compared with previous studies in the Mexican population and also a higher hypothyroidism incidence.