Impact of Associated Significant Aortic Regurgitation on Left Ventricular Remodeling and Hemodynamic Impairment in Severe Aortic Valve Stenosis

Objectives: The left ventricular (LV) response to combined pressure and volume overload [aortic stenosis (AS) and aortic regurgitation (AR)] versus pressure overload (isolated AS) has not been systematically studied. We aimed to assess LV remodeling, functional and hemodynamic consequences in patien...

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Veröffentlicht in:	Cardiology 2013-01, Vol.124 (3), p.174-181
Hauptverfasser:	Popescu, Andreea Catarina, Antonini-Canterin, Francesco, Enache, Roxana, Nicolosi, Gian Luigi, Piazza, Rita, Faggiano, Pompilio, Cassin, Matteo, Dimulescu, Doina, Ginghină, Carmen, Popescu, Bogdan Alexandru
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aortic Valve Insufficiency - complications Aortic Valve Insufficiency - physiopathology Aortic Valve Stenosis - complications Aortic Valve Stenosis - physiopathology Cardiac Catheterization Cardiac Output - physiology Cardiology Cardiovascular disease Coronary vessels Echocardiography Female Hemodynamics - physiology Humans Male Original Research Pulmonary Wedge Pressure - physiology Stroke Volume - physiology Ventricular Remodeling - physiology
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Zusammenfassung:	Objectives: The left ventricular (LV) response to combined pressure and volume overload [aortic stenosis (AS) and aortic regurgitation (AR)] versus pressure overload (isolated AS) has not been systematically studied. We aimed to assess LV remodeling, functional and hemodynamic consequences in patients with mixed aortic valve disease versus patients with isolated AS. Methods: We enrolled 181 patients (67 ± 9 years, 109 men) with severe AS (aortic valve area indexed to body surface area
ISSN:	0008-6312 1421-9751
DOI:	10.1159/000346623