Severity of arthritis is predicted by antibody response to gp135 in chronic infection with caprine arthritis-encephalitis virus

Antibody titers to caprine arthritis-encephalitis virus surface glycoprotein gp135 and core protein p28 in synovial fluid and serum from 35 goats infected for 3 years were compared with the histologic severity of arthritis in these animals. Anti-gp135 antibody titers in synovial fluid and serum dire...

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Veröffentlicht in:	Journal of Virology 1990-05, Vol.64 (5), p.2396-2398
Hauptverfasser:	Knowles, D. Jr. (Animal Disease Research Unit, USDA, ARS, Pullman, WA), Cheevers, W, McGuire, T, Stem, T, Gorham, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - analysis Antibody Formation ANTICORPS ANTICUERPOS ARTHRITE Arthritis, Infectious - immunology Arthritis, Infectious - microbiology Arthritis, Infectious - veterinary ARTRITIS Biological and medical sciences CAPRIN CAPRINOS ENCEFALITIS ENCEPHALITE Encephalitis - immunology Encephalitis - microbiology Encephalitis - veterinary Experimental viral diseases and models GLICOPROTEINAS GLYCOPROTEINE Goat Diseases - immunology Goat Diseases - microbiology Goat Diseases - physiopathology Goats Infectious diseases LENTIVIRINAE Medical sciences PODER PATOGENO POUVOIR PATHOGENE REPONSE IMMUNITAIRE RESPUESTA INMUNOLOGICA Retroviridae - immunology Retroviridae - pathogenicity Synovial Fluid - immunology Viral diseases Viral Envelope Proteins - immunology
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Beschreibung
Zusammenfassung:	Antibody titers to caprine arthritis-encephalitis virus surface glycoprotein gp135 and core protein p28 in synovial fluid and serum from 35 goats infected for 3 years were compared with the histologic severity of arthritis in these animals. Anti-gp135 antibody titers in synovial fluid and serum directly reflect the severity of carpal arthritis in chronically infected goats
ISSN:	0022-538X 1098-5514
DOI:	10.1128/JVI.64.5.2396-2398.1990