Glucocorticosteroids Rescue Basophils from Dasatinib-Augmented Immunoglobulin E-Mediated Histamine Release

Background: Dasatinib is a multikinase inhibitor active against several tyrosine kinases including ABL, KIT, Lyn and Btk. Apart from its known antileukemic activity, the drug produces several side effects including edemas and pleural effusions, which are supposedly triggered by activated immune cell...

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Veröffentlicht in:	International archives of allergy and immunology 2012-01, Vol.159 (1), p.15-22
Hauptverfasser:	Herrmann, Harald, Blatt, Katharina, Ghanim, Viviane, Kneidinger, Michael, Marth, Katharina, Valenta, Rudolf, Valent, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - immunology Antigens, Plant - immunology Basophils - drug effects Basophils - immunology Biological and medical sciences Cells, Cultured Dasatinib Fundamental and applied biological sciences. Psychology Fundamental immunology Glucocorticoids - pharmacology Histamine Histamine Release - drug effects Hormones Humans Immunoglobulin E - immunology Immunoglobulins Immunopathology Inhibitor drugs Kinases Medical sciences Original Paper Plant Proteins - immunology Pregnanes - pharmacology Protein Kinase Inhibitors - adverse effects Pyrimidines - adverse effects Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Side effects Thiazoles - adverse effects
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Zusammenfassung:	Background: Dasatinib is a multikinase inhibitor active against several tyrosine kinases including ABL, KIT, Lyn and Btk. Apart from its known antileukemic activity, the drug produces several side effects including edemas and pleural effusions, which are supposedly triggered by activated immune cells. Effusion formation can be treated effectively by glucocorticosteroids. We have recently shown that low concentrations of dasatinib (
ISSN:	1018-2438 1423-0097
DOI:	10.1159/000335146