Development and evaluation of carvedilol-loaded transdermal drug delivery system: In-vitro and in-vivo characterization study

Context: The transdermal drug delivery system was prepared and the bioavailability of the selected drug was enhanced by reducing first-pass metabolism. Objective: The objective of this study was to enhance the bioavailability of carvedilol through transdermal patches. Materials and methods: To devel...

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Veröffentlicht in:	Drug development and industrial pharmacy 2012-12, Vol.38 (12), p.1530-1537
Hauptverfasser:	Kshirsagar, Sanjay J., Bhalekar, Mangesh R., Mohapatra, Santosh K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Animals antihypertensive Antihypertensive Agents - administration & dosage Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacokinetics bioavailability Biological Availability Carbazoles - administration & dosage Carbazoles - chemistry Carbazoles - pharmacokinetics carvedilol Drug Delivery Systems - methods ethyl cellulose histocompatibility Male polyvinyl pyrrolidone Propanolamines - administration & dosage Propanolamines - chemistry Propanolamines - pharmacokinetics Rats Rats, Wistar Skin Absorption - drug effects Transdermal Transdermal Patch
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