Effects of Artemisinin Dimers on Rat Breast Cancer Cells In Vitro and In Vivo

Artemisinin has been shown to be an effective antimalarial and anticancer compound. Dimers of artemisinin have been synthesized and shown to be potent antimalarials compared with monomers. In the present study, we investigated the effect of two artemisinin dimers (dimer-alcohol and dimer-hydrazone)...

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Veröffentlicht in:	Anticancer research 2011-12, Vol.31 (12), p.4111-4114
Hauptverfasser:	SINGH, Narendra P, LAI, Henry C, PARK, Ji Sun, GERHARDT, Thomas E, KIM, Byung Ju, SHUSHENG WANG, SASAKI, Tomikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols - chemistry Animals Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antioxidants - chemistry Artemisinins - chemistry Artemisinins - pharmacology Biological and medical sciences Cell Line, Tumor Dimerization Female Gynecology. Andrology. Obstetrics Humans In Vitro Techniques Inhibitory Concentration 50 Mammary gland diseases Mammary Neoplasms, Animal - drug therapy Mammary Neoplasms, Animal - metabolism Medical sciences Models, Chemical Rats Rats, Inbred F344 Time Factors Tumors
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Zusammenfassung:	Artemisinin has been shown to be an effective antimalarial and anticancer compound. Dimers of artemisinin have been synthesized and shown to be potent antimalarials compared with monomers. In the present study, we investigated the effect of two artemisinin dimers (dimer-alcohol and dimer-hydrazone) on rat mammary adenocarcinoma cells (MTLn3) in vitro and in vivo compared with that of the artemisinin monomer dihydroartemisinin (DHA). We found that the dimers are considerably more potent than DHA in killing MTLn3 cells in vitro and suppressing the growth of MTLn3 breast tumors in vivo.
ISSN:	0250-7005 1791-7530