Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls
Immune system development, particularly in the pre-natal and early post-natal periods, has far-reaching health consequences during childhood, as well as throughout life. Exposure to poly-chlorinated biphenyls (PCBs) during pre-natal and early life has been previously associated with changes in the i...
Gespeichert in:
| Veröffentlicht in: | Journal of immunotoxicology 2011-10, Vol.8 (4), p.333-345 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 345 |
|---|---|
| container_issue | 4 |
| container_start_page | 333 |
| container_title | Journal of immunotoxicology |
| container_volume | 8 |
| creator | Horváthová, M. Jahnová, E. Palkovi ová, . Trnovec, T. Hertz-Picciotto, I. |
| description | Immune system development, particularly in the pre-natal and early post-natal periods, has far-reaching health consequences during childhood, as well as throughout life. Exposure to poly-chlorinated biphenyls (PCBs) during pre-natal and early life has been previously associated with changes in the incidence of infectious and allergic diseases in children, and humoral immunity alterations. Lymphocyte immunophenotyping is an important tool in the diagnosis of immunologic and hematologic disorders. This study used a lysed whole blood method for analysis of lymphocyte sub-populations in samples from children born and living in two districts: a highly-contaminated area (Michalovce) and one (Svidnik/Stropkov) with 2-fold lower environmental PCB levels. The percentages of B-lymphocytes (CD19+), activated HLADR+CD19+ cells, and CD8+ T-lymphocytes significantly increased at 6- and 16-months-of-age in both selected regions as compared to in cord blood values (p |
| doi_str_mv | 10.3109/1547691X.2011.615767 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_22013978</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>902343904</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-566b1d57abe32d031a759d97f43ea2ef1cf88295edf2d06f72792947d7e32e453</originalsourceid><addsrcrecordid>eNp9kE9LHTEUxUOpqLV-g1Jm19V7zZ-ZyctGEbWtIHTTgruQSW46kUwyJjMt8-3N9KngRgjkcnLOueGH0CeCt4xg8ZU0NW8FudtSTMi2JQ1v-Tt0vMqbVmDy_mUmd0foQ873GFNBGD5ER7RkmOC7Y9RdLUENTucq2sovw9hHvUxQ5bnLMOXKhUr3zpsEofLurwt_VkmVk0BVY_R-nsBU3bLOi-59TC6o_5IbewiLzx_RgVU-w-nTfYJ-f7v-dfljc_vz-83lxe1G1zs2bZq27YhpuOqAUYMZUbwRRnBbM1AULNF2t6OiAWPLc2s55YKKmhte_FA37AR92feOKT7MkCc5uKzBexUgzlkKTFnNBK6Ls947dYo5J7ByTG5QaZEEyxWufIYrV7hyD7fEPj8tmLsBzEvomWYxnO8NLtiYBvUvJm_kpJZCxSYVtMtr_Zsrzl419KD81OsCW97HOYXC7-0_PgKVb543</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>902343904</pqid></control><display><type>article</type><title>Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Horváthová, M. ; Jahnová, E. ; Palkovi ová, . ; Trnovec, T. ; Hertz-Picciotto, I.</creator><creatorcontrib>Horváthová, M. ; Jahnová, E. ; Palkovi ová, . ; Trnovec, T. ; Hertz-Picciotto, I.</creatorcontrib><description>Immune system development, particularly in the pre-natal and early post-natal periods, has far-reaching health consequences during childhood, as well as throughout life. Exposure to poly-chlorinated biphenyls (PCBs) during pre-natal and early life has been previously associated with changes in the incidence of infectious and allergic diseases in children, and humoral immunity alterations. Lymphocyte immunophenotyping is an important tool in the diagnosis of immunologic and hematologic disorders. This study used a lysed whole blood method for analysis of lymphocyte sub-populations in samples from children born and living in two districts: a highly-contaminated area (Michalovce) and one (Svidnik/Stropkov) with 2-fold lower environmental PCB levels. The percentages of B-lymphocytes (CD19+), activated HLADR+CD19+ cells, and CD8+ T-lymphocytes significantly increased at 6- and 16-months-of-age in both selected regions as compared to in cord blood values (p < 0.001). Levels of CD3+ cells increased significantly (from 61 to 65%) in samples from Michalovce (p < 0.01). Levels of CD4+ T-lymphocytes declined 10% among 16-month-olds in both regions (Michalovce at p < 0.001 and Svidnik/Stropkov at p < 0.01). Natural killer (NK) cell levels decreased 50% in Michalovce 6- and 16-month-old children and 42% among 6-month-olds in Svidnik/Stropkov (p < 0.001). Compared with the less-contaminated region, Michalovce samples showed significantly higher expression of CD3+ T-lymphocytes, B-lymphocytes, and activated B-lymphocytes, whereas NK cells were less expressed. Even after adjustment for selected covariates, e.g., maternal cigarette smoking, age, parity, ethnicity, birth weight, and gender of infant, the levels of CD19+, HLADR+CD19+, and CD3−CD(16 + 56)+ cells were seen to remain significantly different between the districts. These results showed that early-life environmental PCB exposure was associated with fluctuations in major lymphocyte subsets in children, suggesting that there is a post-natal immune system response to PCB exposures.</description><identifier>ISSN: 1547-691X</identifier><identifier>EISSN: 1547-6901</identifier><identifier>DOI: 10.3109/1547691X.2011.615767</identifier><identifier>PMID: 22013978</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Adolescent ; Adult ; CD markers ; cord blood ; Environmental Exposure - adverse effects ; Environmental Monitoring ; Environmental Pollutants - adverse effects ; environmental pollution ; Female ; Fetal Blood - cytology ; Fetal Blood - drug effects ; Humans ; Immune System - drug effects ; Immunophenotyping ; infant ; Lymphocyte Subsets - drug effects ; lymphocytes ; Male ; Maternal Exposure - adverse effects ; natural killer cells ; polychlorinated biphenyls ; Polychlorinated Biphenyls - adverse effects ; post-natal exposure ; pre-natal exposure ; Pregnancy - blood ; Prenatal Exposure Delayed Effects - chemically induced ; Prenatal Exposure Delayed Effects - immunology ; Prenatal Exposure Delayed Effects - pathology ; Young Adult</subject><ispartof>Journal of immunotoxicology, 2011-10, Vol.8 (4), p.333-345</ispartof><rights>2011 Informa Healthcare USA, Inc. 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-566b1d57abe32d031a759d97f43ea2ef1cf88295edf2d06f72792947d7e32e453</citedby><cites>FETCH-LOGICAL-c483t-566b1d57abe32d031a759d97f43ea2ef1cf88295edf2d06f72792947d7e32e453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22013978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horváthová, M.</creatorcontrib><creatorcontrib>Jahnová, E.</creatorcontrib><creatorcontrib>Palkovi ová, .</creatorcontrib><creatorcontrib>Trnovec, T.</creatorcontrib><creatorcontrib>Hertz-Picciotto, I.</creatorcontrib><title>Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls</title><title>Journal of immunotoxicology</title><addtitle>J Immunotoxicol</addtitle><description>Immune system development, particularly in the pre-natal and early post-natal periods, has far-reaching health consequences during childhood, as well as throughout life. Exposure to poly-chlorinated biphenyls (PCBs) during pre-natal and early life has been previously associated with changes in the incidence of infectious and allergic diseases in children, and humoral immunity alterations. Lymphocyte immunophenotyping is an important tool in the diagnosis of immunologic and hematologic disorders. This study used a lysed whole blood method for analysis of lymphocyte sub-populations in samples from children born and living in two districts: a highly-contaminated area (Michalovce) and one (Svidnik/Stropkov) with 2-fold lower environmental PCB levels. The percentages of B-lymphocytes (CD19+), activated HLADR+CD19+ cells, and CD8+ T-lymphocytes significantly increased at 6- and 16-months-of-age in both selected regions as compared to in cord blood values (p < 0.001). Levels of CD3+ cells increased significantly (from 61 to 65%) in samples from Michalovce (p < 0.01). Levels of CD4+ T-lymphocytes declined 10% among 16-month-olds in both regions (Michalovce at p < 0.001 and Svidnik/Stropkov at p < 0.01). Natural killer (NK) cell levels decreased 50% in Michalovce 6- and 16-month-old children and 42% among 6-month-olds in Svidnik/Stropkov (p < 0.001). Compared with the less-contaminated region, Michalovce samples showed significantly higher expression of CD3+ T-lymphocytes, B-lymphocytes, and activated B-lymphocytes, whereas NK cells were less expressed. Even after adjustment for selected covariates, e.g., maternal cigarette smoking, age, parity, ethnicity, birth weight, and gender of infant, the levels of CD19+, HLADR+CD19+, and CD3−CD(16 + 56)+ cells were seen to remain significantly different between the districts. These results showed that early-life environmental PCB exposure was associated with fluctuations in major lymphocyte subsets in children, suggesting that there is a post-natal immune system response to PCB exposures.</description><subject>Adolescent</subject><subject>Adult</subject><subject>CD markers</subject><subject>cord blood</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Monitoring</subject><subject>Environmental Pollutants - adverse effects</subject><subject>environmental pollution</subject><subject>Female</subject><subject>Fetal Blood - cytology</subject><subject>Fetal Blood - drug effects</subject><subject>Humans</subject><subject>Immune System - drug effects</subject><subject>Immunophenotyping</subject><subject>infant</subject><subject>Lymphocyte Subsets - drug effects</subject><subject>lymphocytes</subject><subject>Male</subject><subject>Maternal Exposure - adverse effects</subject><subject>natural killer cells</subject><subject>polychlorinated biphenyls</subject><subject>Polychlorinated Biphenyls - adverse effects</subject><subject>post-natal exposure</subject><subject>pre-natal exposure</subject><subject>Pregnancy - blood</subject><subject>Prenatal Exposure Delayed Effects - chemically induced</subject><subject>Prenatal Exposure Delayed Effects - immunology</subject><subject>Prenatal Exposure Delayed Effects - pathology</subject><subject>Young Adult</subject><issn>1547-691X</issn><issn>1547-6901</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LHTEUxUOpqLV-g1Jm19V7zZ-ZyctGEbWtIHTTgruQSW46kUwyJjMt8-3N9KngRgjkcnLOueGH0CeCt4xg8ZU0NW8FudtSTMi2JQ1v-Tt0vMqbVmDy_mUmd0foQ873GFNBGD5ER7RkmOC7Y9RdLUENTucq2sovw9hHvUxQ5bnLMOXKhUr3zpsEofLurwt_VkmVk0BVY_R-nsBU3bLOi-59TC6o_5IbewiLzx_RgVU-w-nTfYJ-f7v-dfljc_vz-83lxe1G1zs2bZq27YhpuOqAUYMZUbwRRnBbM1AULNF2t6OiAWPLc2s55YKKmhte_FA37AR92feOKT7MkCc5uKzBexUgzlkKTFnNBK6Ls947dYo5J7ByTG5QaZEEyxWufIYrV7hyD7fEPj8tmLsBzEvomWYxnO8NLtiYBvUvJm_kpJZCxSYVtMtr_Zsrzl419KD81OsCW97HOYXC7-0_PgKVb543</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Horváthová, M.</creator><creator>Jahnová, E.</creator><creator>Palkovi ová, .</creator><creator>Trnovec, T.</creator><creator>Hertz-Picciotto, I.</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls</title><author>Horváthová, M. ; Jahnová, E. ; Palkovi ová, . ; Trnovec, T. ; Hertz-Picciotto, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-566b1d57abe32d031a759d97f43ea2ef1cf88295edf2d06f72792947d7e32e453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>CD markers</topic><topic>cord blood</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental Monitoring</topic><topic>Environmental Pollutants - adverse effects</topic><topic>environmental pollution</topic><topic>Female</topic><topic>Fetal Blood - cytology</topic><topic>Fetal Blood - drug effects</topic><topic>Humans</topic><topic>Immune System - drug effects</topic><topic>Immunophenotyping</topic><topic>infant</topic><topic>Lymphocyte Subsets - drug effects</topic><topic>lymphocytes</topic><topic>Male</topic><topic>Maternal Exposure - adverse effects</topic><topic>natural killer cells</topic><topic>polychlorinated biphenyls</topic><topic>Polychlorinated Biphenyls - adverse effects</topic><topic>post-natal exposure</topic><topic>pre-natal exposure</topic><topic>Pregnancy - blood</topic><topic>Prenatal Exposure Delayed Effects - chemically induced</topic><topic>Prenatal Exposure Delayed Effects - immunology</topic><topic>Prenatal Exposure Delayed Effects - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horváthová, M.</creatorcontrib><creatorcontrib>Jahnová, E.</creatorcontrib><creatorcontrib>Palkovi ová, .</creatorcontrib><creatorcontrib>Trnovec, T.</creatorcontrib><creatorcontrib>Hertz-Picciotto, I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of immunotoxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horváthová, M.</au><au>Jahnová, E.</au><au>Palkovi ová, .</au><au>Trnovec, T.</au><au>Hertz-Picciotto, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls</atitle><jtitle>Journal of immunotoxicology</jtitle><addtitle>J Immunotoxicol</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>8</volume><issue>4</issue><spage>333</spage><epage>345</epage><pages>333-345</pages><issn>1547-691X</issn><eissn>1547-6901</eissn><abstract>Immune system development, particularly in the pre-natal and early post-natal periods, has far-reaching health consequences during childhood, as well as throughout life. Exposure to poly-chlorinated biphenyls (PCBs) during pre-natal and early life has been previously associated with changes in the incidence of infectious and allergic diseases in children, and humoral immunity alterations. Lymphocyte immunophenotyping is an important tool in the diagnosis of immunologic and hematologic disorders. This study used a lysed whole blood method for analysis of lymphocyte sub-populations in samples from children born and living in two districts: a highly-contaminated area (Michalovce) and one (Svidnik/Stropkov) with 2-fold lower environmental PCB levels. The percentages of B-lymphocytes (CD19+), activated HLADR+CD19+ cells, and CD8+ T-lymphocytes significantly increased at 6- and 16-months-of-age in both selected regions as compared to in cord blood values (p < 0.001). Levels of CD3+ cells increased significantly (from 61 to 65%) in samples from Michalovce (p < 0.01). Levels of CD4+ T-lymphocytes declined 10% among 16-month-olds in both regions (Michalovce at p < 0.001 and Svidnik/Stropkov at p < 0.01). Natural killer (NK) cell levels decreased 50% in Michalovce 6- and 16-month-old children and 42% among 6-month-olds in Svidnik/Stropkov (p < 0.001). Compared with the less-contaminated region, Michalovce samples showed significantly higher expression of CD3+ T-lymphocytes, B-lymphocytes, and activated B-lymphocytes, whereas NK cells were less expressed. Even after adjustment for selected covariates, e.g., maternal cigarette smoking, age, parity, ethnicity, birth weight, and gender of infant, the levels of CD19+, HLADR+CD19+, and CD3−CD(16 + 56)+ cells were seen to remain significantly different between the districts. These results showed that early-life environmental PCB exposure was associated with fluctuations in major lymphocyte subsets in children, suggesting that there is a post-natal immune system response to PCB exposures.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>22013978</pmid><doi>10.3109/1547691X.2011.615767</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1547-691X |
| ispartof | Journal of immunotoxicology, 2011-10, Vol.8 (4), p.333-345 |
| issn | 1547-691X 1547-6901 |
| language | eng |
| recordid | cdi_pubmed_primary_22013978 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult CD markers cord blood Environmental Exposure - adverse effects Environmental Monitoring Environmental Pollutants - adverse effects environmental pollution Female Fetal Blood - cytology Fetal Blood - drug effects Humans Immune System - drug effects Immunophenotyping infant Lymphocyte Subsets - drug effects lymphocytes Male Maternal Exposure - adverse effects natural killer cells polychlorinated biphenyls Polychlorinated Biphenyls - adverse effects post-natal exposure pre-natal exposure Pregnancy - blood Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - immunology Prenatal Exposure Delayed Effects - pathology Young Adult |
| title | Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T20%3A56%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dynamics%20of%20lymphocyte%20subsets%20in%20children%20living%20in%20an%20area%20polluted%20by%20polychlorinated%20biphenyls&rft.jtitle=Journal%20of%20immunotoxicology&rft.au=Horv%C3%A1thov%C3%A1,%20M.&rft.date=2011-10-01&rft.volume=8&rft.issue=4&rft.spage=333&rft.epage=345&rft.pages=333-345&rft.issn=1547-691X&rft.eissn=1547-6901&rft_id=info:doi/10.3109/1547691X.2011.615767&rft_dat=%3Cproquest_pubme%3E902343904%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=902343904&rft_id=info:pmid/22013978&rfr_iscdi=true |