Genomic Analysis at the Single-Cell Level

Genomic Analysis at the Single-Cell Level

Studying complex biological systems such as a developing embryo, a tumor, or a microbial ecosystem often involves understanding the behavior and heterogeneity of the individual cells that constitute the system and their interactions. In this review, we discuss a variety of approaches to single-cell...

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Veröffentlicht in:Annual review of genetics 2011-01, Vol.45 (1), p.431-445
Hauptverfasser: Kalisky, Tomer, Blainey, Paul, Quake, Stephen R
Format: Artikel
Sprache:eng
Schlagworte:
Biology
Cells
Cells - cytology
FACS
FISH
Flow Cytometry
gene expression
Genomics
Genomics - methods
Heterogeneity
High-Throughput Screening Assays
Humans
Microscopy
Polymerase Chain Reaction - methods
qPCR
Sequence Analysis, RNA
sequencing
single cell
Single-Cell Analysis - instrumentation
Single-Cell Analysis - methods
Tissue Array Analysis
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Beschreibung
Zusammenfassung:Studying complex biological systems such as a developing embryo, a tumor, or a microbial ecosystem often involves understanding the behavior and heterogeneity of the individual cells that constitute the system and their interactions. In this review, we discuss a variety of approaches to single-cell genomic analysis.
ISSN:0066-4197
1545-2948
DOI:10.1146/annurev-genet-102209-163607