Actin Stress Fiber Retraction and Aggresome Formation Is a Common Cellular Response to Actin Toxins

F-actin-stabilizing drugs induce actin aggresome formation. In this study, we found that an actin-depolymerizing drug, latrunculin A (LatA), induced actin aggresomes. Actin stress fibers were retracted and disappeared in minutes, but a large aggresome formed in consequence of LatA treatment. Because...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2011, Vol.75 (9), p.1853-1855
Hauptverfasser:	KAZAMI, Sayaka, USUI, Takeo, OSADA, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	actin actin toxin Actins - metabolism aggresome Animals Biological and medical sciences Bridged Bicyclo Compounds, Heterocyclic - adverse effects Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cell Line, Tumor Cell Survival - drug effects Cytochalasin D - adverse effects Cytochalasin D - pharmacology Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Fibrosarcoma - metabolism Fibrosarcoma - pathology Fundamental and applied biological sciences. Psychology Humans latrunculin A Marine Toxins - adverse effects Marine Toxins - pharmacology Microscopy, Fluorescence Microscopy, Video Protein Folding - drug effects Rats Stress Fibers - drug effects Stress, Physiological Thiazolidines - adverse effects Thiazolidines - pharmacology
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Zusammenfassung:	F-actin-stabilizing drugs induce actin aggresome formation. In this study, we found that an actin-depolymerizing drug, latrunculin A (LatA), induced actin aggresomes. Actin stress fibers were retracted and disappeared in minutes, but a large aggresome formed in consequence of LatA treatment. Because cytochalasin D and mycalolide also induced aggresome formation, these results suggest that actin aggresome formation is a common cellular response to actin toxins.
ISSN:	0916-8451 1347-6947 1347-6947
DOI:	10.1271/bbb.110334